H4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 25, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02R03G.hns1N19E22Y23G.H5GproteinT34x55Q34x56K-R34x54H-S3x53H-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H5GPCR segments:ICL2TM3ICL4

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x433x493x503x533x5434x5034x5134x5334x5434x5534x565x615x656x337x568x49G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.18G.H5.16G.H5.15G.H5.12G.S1.02G.hns1.03G.hns1.02G.HN.52Res. Pos.H4 (7YFC)- (7YFC)------------------SFDRSVAVYRTQILLCRSFAVYRTQDRSVILLCRKYILNKMELRRLLVNRQ

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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