S1P1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8G94

RESOLUTION

3.2 Å

REFERENCE

10.7554/ELIFE.88204

PUBLICATION DATE

April 19, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

18 interactions (Click to see)

LIGANDS

Early activation antigen CD69 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 M 80 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 M 80 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 151 - G.S1 E 33 G.S1.01
Hydrophobic TM5 V 228 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 235 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 235 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 239 - G.S6 Y 320 G.S6.02
Polar TM3 T 145 3x53 G.H5 N 347 G.H5.19
Polar ICL2 N 153 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 N 153 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 N 153 - G.H5 D 350 G.H5.22
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 F 237 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 F 237 - G.H5 F 334 G.H5.06
Ionic ICL2 K 150 - G.H5 D 350 G.H5.22
Polar ICL2 K 150 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 150 - G.H5 D 350 G.H5.22
Polar ICL3 T 236 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 T 236 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 L 151 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 235 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 237 - G.H5 A 338 G.H5.10
Hydrophobic TM3 T 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 142 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 M 146 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 146 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL1 M 80 - G.H5 C 351 G.H5.23
Van-der-waals ICL1 M 80 - G.H5 C 351 G.H5.23
Aromatic ICL3 F 237 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 237 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 R 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals ICL3 K 239 - G.H4 Q 304 G.H4.12
Polar ICL2 M 149 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 149 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 149 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 235 - G.H5 D 337 G.H5.09
Hydrophobic TM3 M 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 146 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 M 146 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 146 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 254 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 257 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 151 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 151 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 M 149 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 237 - G.H5 D 337 G.H5.09
Hydrophobic TM6 L 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 149 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 F 237 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 F 237 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 H 152 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 152 - G.hns1 A 31 G.hns1.02