CB2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8GUQ

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41467-023-37112-9

PUBLICATION DATE

May 10, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

37 interactions (Click to see)

LIGANDS

olorinab - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

2-arachidonoylglycerol, anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 141 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 141 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 140 - G.hns1 R 32 G.hns1.03
Ionic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 223 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM3 C 134 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 223 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 223 5x72 G.H5 D 341 G.H5.13
Polar TM3 C 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 134 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 134 3x53 G.H5 C 351 G.H5.23
Polar TM2 Y 70 2x40 G.H5 K 349 G.H5.21
Polar H8 G 304 8x48 G.H5 F 354 G.H5.26
Polar TM2 S 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 69 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 247 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 247 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 223 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM6 L 239 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 239 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 141 - G.H5 D 350 G.H5.22
Hydrophobic TM2 I 73 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 73 2x43 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 239 6x29 G.H5 I 344 G.H5.16
Polar TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 69 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 138 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 343 G.H5.15
Hydrophobic TM6 L 239 6x29 G.H5 K 345 G.H5.17
Polar TM2 Y 70 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 70 2x40 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 139 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 139 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 K 142 - G.H5 D 350 G.H5.22
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Aromatic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 143 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 H 219 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 243 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 H 226 - G.S6 H 322 G.S6.04
Hydrophobic TM6 L 243 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 223 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 223 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM2 K 67 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 67 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 223 5x72 G.S6 Y 320 G.S6.02
Polar ICL3 H 226 - G.H5 Q 333 G.H5.05
Hydrophobic ICL3 H 226 - G.H5 Q 333 G.H5.05
Van-der-waals ICL3 H 226 - G.H5 Q 333 G.H5.05
Hydrophobic TM6 L 243 6x33 G.H5 L 348 G.H5.20
Ionic ICL3 H 226 - G.H5 D 337 G.H5.09
Polar ICL3 H 226 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 H 226 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 H 226 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 138 - G.H5 I 344 G.H5.16
Polar TM3 C 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 H 226 - G.H5 F 334 G.H5.06
Polar TM5 S 222 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM6 T 246 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 246 6x36 G.H5 L 353 G.H5.25
Polar ICL2 P 138 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 138 - G.H5 N 347 G.H5.19
Hydrophobic TM5 H 219 5x68 G.H5 T 340 G.H5.12
Polar H8 S 303 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 303 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 303 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 139 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 139 - G.S3 L 194 G.S3.01
Hydrophobic TM3 L 135 3x54 G.H5 I 344 G.H5.16