CB2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

May 10, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CP55940 - Agonist pubchem gtoplig chembl_ligand gtoplig

PHYSIOLOGICAL LIGANDS

2-arachidonoylglycerol, anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
H04G.S6D09T12C23G24F26G.H5GproteinC3x53G8x48H-H5x68S8x47GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S6G.H5GPCR segments:TM3ICL3TM5H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x392x403x503x533x545x685x726x296x326x336x366x378x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.10G.H5.09G.H5.06G.H5.05G.H5.02G.S6.04G.S6.02G.S3.01G.hns1.03G.HN.52Res. Pos.CB2 (8GUR)- (8GUR)----------------KSYRCLHLLRLTLSGKSYRCLHLLRLTLSGHDCGLNLITDDAYKFKQFIELHR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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