A2B receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Jan. 18, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM5 Q 212 5x68 G.H5 Q 236 G.H5.16
Hydrophobic TM5 Q 212 5x68 G.H5 Q 236 G.H5.16
Van-der-waals TM5 Q 212 5x68 G.H5 Q 236 G.H5.16
Hydrophobic TM5 A 209 5x65 G.H5 L 240 G.H5.20
Polar H8 R 295 8x48 G.H5 R 241 G.H5.21
Hydrophobic H8 R 295 8x48 G.H5 R 241 G.H5.21
Van-der-waals H8 R 295 8x48 G.H5 R 241 G.H5.21
Hydrophobic ICL2 R 112 - G.S3 V 79 G.S3.01
Hydrophobic TM3 A 106 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 106 3x53 G.H5 Y 243 G.H5.23
Ionic ICL4 R 293 - G.H5 E 244 G.H5.24
Hydrophobic ICL4 R 293 - G.H5 E 244 G.H5.24
Van-der-waals ICL4 R 293 - G.H5 E 244 G.H5.24
Aromatic ICL2 Y 113 - G.H5 H 239 G.H5.19
Hydrophobic ICL2 Y 113 - G.H5 H 239 G.H5.19
Hydrophobic TM3 I 107 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM5 V 208 5x64 G.H5 Q 236 G.H5.16
Van-der-waals TM5 V 208 5x64 G.H5 Q 236 G.H5.16
Polar TM3 I 107 3x54 G.H5 Q 236 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 236 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 236 G.H5.16
Hydrophobic ICL2 P 110 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 P 110 - G.H2 I 235 G.H2.08
Hydrophobic ICL2 K 114 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 114 - G.hns1 R 38 G.hns1.02
Polar TM5 Q 212 5x68 G.H5 D 233 G.H5.13
Ionic TM5 R 215 5x71 G.H5 D 233 G.H5.13
Polar TM5 R 215 5x71 G.H5 D 233 G.H5.13
Van-der-waals TM5 R 215 5x71 G.H5 D 233 G.H5.13
Polar TM5 Q 212 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 Q 212 5x68 G.H5 R 237 G.H5.17
Van-der-waals TM5 Q 212 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 I 205 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM5 I 205 5x61 G.H5 L 245 G.H5.25
Hydrophobic TM5 R 215 5x71 G.H5 R 237 G.H5.17
Hydrophobic TM6 L 236 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 236 6x37 G.H5 L 245 G.H5.25
Aromatic TM3 R 103 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM5 Q 212 5x68 G.H5 L 240 G.H5.20
Hydrophobic TM5 T 216 5x72 G.h4s6 Y 210 G.h4s6.20
Hydrophobic ICL2 P 110 - G.H5 H 239 G.H5.19
Hydrophobic ICL2 L 111 - G.H5 C 231 G.H5.11
Hydrophobic ICL2 L 111 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 L 111 - G.H5 R 232 G.H5.12
Hydrophobic ICL2 L 111 - G.H2 I 235 G.H2.08
Hydrophobic ICL2 L 111 - G.S3 V 79 G.S3.01
Hydrophobic TM3 I 107 3x54 G.H5 Y 243 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 243 G.H5.23
Ionic H8 R 298 8x51 G.H5 E 244 G.H5.24
Hydrophobic ICL2 S 115 - G.hns1 A 39 G.hns1.03
Polar TM3 A 106 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 239 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 H 239 G.H5.19
Hydrophobic ICL2 P 110 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 P 110 - G.H5 R 232 G.H5.12
Hydrophobic TM5 T 216 5x72 G.H4 L 346 G.H4.16
Hydrophobic TM5 T 216 5x72 G.H5 R 237 G.H5.17
Van-der-waals TM5 T 216 5x72 G.H5 R 237 G.H5.17
Polar H8 R 295 8x48 G.H5 Q 242 G.H5.22
Hydrophobic H8 R 295 8x48 G.H5 Q 242 G.H5.22
Hydrophobic TM5 L 213 5x69 G.H4 L 346 G.H4.16
Van-der-waals TM5 L 213 5x69 G.H4 L 346 G.H4.16
Hydrophobic TM6 A 232 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM3 I 107 3x54 G.H5 L 245 G.H5.25
Polar ICL2 L 111 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 111 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 111 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 111 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 111 - G.H5 F 228 G.H5.08
Hydrophobic ICL2 L 111 - G.S3 F 81 G.S3.03
Hydrophobic H8 R 295 8x48 G.H5 E 244 G.H5.24
Hydrophobic ICL2 P 110 - G.H5 Q 236 G.H5.16