GPR21 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HJ1

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-023-35882-W

PUBLICATION DATE

Dec. 27, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 L 135 - G.H5 C 379 G.H5.11
Hydrophobic TM5 I 225 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 225 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 228 5x76 G.H4 L 346 G.H4.16
Hydrophobic TM5 R 228 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 F 232 5x80 G.H4 R 347 G.H4.17
Hydrophobic ICL2 L 135 - G.S3 V 217 G.S3.01
Hydrophobic TM6 M 252 6x35 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 137 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 137 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 N 138 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 217 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 L 388 G.H5.20
Polar TM6 V 253 6x36 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 135 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 135 - G.H5 F 376 G.H5.08
Van-der-waals TM5 F 232 5x80 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 135 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 A 251 - G.H5 L 393 G.H5.25
Hydrophobic TM5 I 217 5x65 G.H5 L 388 G.H5.20
Polar TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM6 M 252 6x35 G.H5 Y 391 G.H5.23
Van-der-waals TM6 M 252 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 214 5x62 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 131 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 388 G.H5.20
Polar TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Polar TM5 H 221 5x69 G.H5 R 385 G.H5.17
Aromatic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Polar ICL2 L 135 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 135 - G.S1 H 41 G.S1.02
Hydrophobic TM5 F 232 5x80 G.H4 D 343 G.H4.13
Van-der-waals TM5 F 232 5x80 G.H4 D 343 G.H4.13
Polar TM5 R 228 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 228 5x76 G.S6 C 359 G.S6.01
Hydrophobic TM5 F 232 5x80 G.H4 L 346 G.H4.16
Polar ICL1 H 61 - G.HN K 34 G.HN.51
Aromatic ICL1 H 61 - G.HN K 34 G.HN.51
Hydrophobic ICL1 H 61 - G.HN K 34 G.HN.51
Hydrophobic TM5 C 218 5x66 G.H5 L 388 G.H5.20
Hydrophobic ICL2 T 136 - G.S3 V 217 G.S3.01
Hydrophobic TM6 L 254 6x37 G.H5 Y 391 G.H5.23
Hydrophobic TM5 C 218 5x66 G.H5 L 393 G.H5.25
Van-der-waals TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 134 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 214 5x62 G.H5 Y 391 G.H5.23
Van-der-waals TM5 I 214 5x62 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 225 5x73 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 134 - G.H5 H 387 G.H5.19
Hydrophobic TM5 Y 211 5x59 G.H5 Y 391 G.H5.23
Van-der-waals TM5 Y 211 5x59 G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 253 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 R 228 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 R 228 5x76 G.S6 P 361 G.S6.03
Van-der-waals H8 N 308 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 134 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 134 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 134 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 135 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 135 - G.H5 I 383 G.H5.15
Polar TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 131 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 131 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 M 252 6x35 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 252 6x35 G.H5 L 393 G.H5.25