GPR21 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.8 Å

REFERENCE

PUBLICATION DATE

March 15, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1R12Y19E22N24G.H5GproteinM6x35Y-H-N-H-T3x55R3x50GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H5GPCR segments:ICL1ICL2TM3TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x402x433x503x533x543x554x395x625x665x695x736x356x368x47G.H5.26G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.H5.11G.H5.08G.h4s6.20G.S3.03G.S3.01G.S1.02G.hns1.03G.hns1.02G.HN.52Res. Pos.GPR21 (8HJ2)- (8HJ2)---------------SIRAITPICHIMVNSIRAITPICHIMVNLLYILRQLAYNFCVEHVFRA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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