ADGRE5 - G13

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IKL

RESOLUTION

2.3 Å

REFERENCE

10.1016/J.MOLCEL.2023.12.020

PUBLICATION DATE

Jan. 24, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 K 721 5x64 G.H5 D 217 G.H5.13
Polar TM5 K 721 5x64 G.H5 D 217 G.H5.13
Hydrophobic TM5 K 721 5x64 G.H5 D 217 G.H5.13
Van-der-waals TM5 K 721 5x64 G.H5 D 217 G.H5.13
Hydrophobic ICL2 G 647 - G.hns1 K 31 G.hns1.02
Hydrophobic TM3 V 641 3x58 G.H5 L 220 G.H5.16
Polar ICL2 V 644 - G.H5 N 223 G.H5.19
Van-der-waals ICL2 V 644 - G.H5 N 223 G.H5.19
Hydrophobic TM2 R 579 2x46 G.H5 L 227 G.H5.23
Hydrophobic ICL2 F 645 - G.H5 K 216 G.H5.12
Van-der-waals ICL2 F 645 - G.H5 K 216 G.H5.12
Hydrophobic TM5 K 717 5x60 G.H5 L 224 G.H5.20
Hydrophobic TM3 L 637 3x54 G.H5 L 227 G.H5.23
Hydrophobic TM3 V 641 3x58 G.H5 L 224 G.H5.20
Hydrophobic TM5 K 717 5x60 G.H5 L 220 G.H5.16
Hydrophobic TM5 I 725 5x68 G.H5 M 228 G.H5.24
Hydrophobic ICL2 Q 648 - G.hns1 R 32 G.hns1.03
Polar TM6 T 741 6x41 G.H5 L 229 G.H5.25
Hydrophobic TM6 T 741 6x41 G.H5 L 229 G.H5.25
Hydrophobic TM6 T 741 6x41 G.H5 L 227 G.H5.23
Hydrophobic ICL2 F 645 - G.S3 V 79 G.S3.01
Hydrophobic TM6 I 740 6x40 G.H5 L 229 G.H5.25
Van-der-waals TM6 I 740 6x40 G.H5 L 229 G.H5.25
Hydrophobic ICL2 F 645 - G.S3 F 81 G.S3.03
Hydrophobic TM6 A 744 6x44 G.H5 L 229 G.H5.25
Van-der-waals TM6 A 744 6x44 G.H5 L 229 G.H5.25
Polar TM5 E 724 5x67 G.H5 H 221 G.H5.17
Hydrophobic TM5 E 724 5x67 G.H5 H 221 G.H5.17
Hydrophobic ICL2 F 645 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 F 645 - G.H5 I 219 G.H5.15
Hydrophobic TM5 L 718 5x61 G.H5 L 224 G.H5.20
Hydrophobic TM5 I 725 5x68 G.H5 L 224 G.H5.20
Van-der-waals TM5 I 725 5x68 G.H5 L 224 G.H5.20
Hydrophobic TM6 Q 745 6x45 G.H5 L 227 G.H5.23
Hydrophobic ICL2 V 644 - G.H5 L 220 G.H5.16
Van-der-waals ICL2 V 644 - G.H5 L 220 G.H5.16
Hydrophobic TM3 L 640 3x57 G.H5 L 227 G.H5.23
Hydrophobic TM5 K 721 5x64 G.H5 L 224 G.H5.20
Van-der-waals TM5 K 721 5x64 G.H5 L 224 G.H5.20
Hydrophobic TM7 L 789 7x60 G.H5 L 229 G.H5.25
Van-der-waals TM7 L 789 7x60 G.H5 L 229 G.H5.25
Hydrophobic ICL2 F 645 - G.S1 V 34 G.S1.02
Hydrophobic TM5 T 714 5x57 G.H5 L 227 G.H5.23
Hydrophobic TM5 I 725 5x68 G.H5 K 225 G.H5.21
Hydrophobic ICL2 V 644 - G.H5 K 216 G.H5.12
Hydrophobic ICL2 V 644 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 V 644 - G.H5 I 219 G.H5.15
Hydrophobic TM5 F 722 5x65 G.H5 M 228 G.H5.24
Van-der-waals TM5 F 722 5x65 G.H5 M 228 G.H5.24
Hydrophobic TM5 L 718 5x61 G.H5 M 228 G.H5.24
Van-der-waals TM5 L 718 5x61 G.H5 M 228 G.H5.24
Hydrophobic TM7 L 785 7x56 G.H5 L 229 G.H5.25
Van-der-waals TM7 L 785 7x56 G.H5 L 229 G.H5.25
Hydrophobic TM3 V 641 3x58 G.H5 L 227 G.H5.23
Polar TM3 L 640 3x57 G.H5 N 223 G.H5.19
Hydrophobic TM3 L 640 3x57 G.H5 N 223 G.H5.19
Van-der-waals TM3 L 640 3x57 G.H5 N 223 G.H5.19
Aromatic ICL2 F 645 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 645 - G.H5 F 212 G.H5.08
Van-der-waals ICL2 F 645 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 G 647 - G.hns1 R 32 G.hns1.03
Polar TM5 I 725 5x68 G.H5 H 221 G.H5.17
Hydrophobic TM5 I 725 5x68 G.H5 H 221 G.H5.17
Van-der-waals TM5 I 725 5x68 G.H5 H 221 G.H5.17
Hydrophobic ICL2 F 645 - G.H5 V 215 G.H5.11