FP receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Jan. 31, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

latanoprost (free acid form) - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

PGF, PGI2, PGD2, thromboxane A2, PGE2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
G11G.h4s6Q17E22Y23N24V26G.H5GproteinH6x29F2x39S-H34x53S2x38H6x30R1x63GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM1ICL1TM2ICL2TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null1x601x631x642x372x382x392x403x493x503x533x5434x5034x5134x5334x5434x555x636x296x306x326x337x548x478x498x50G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.H5.08G.h4s6.11G.S3.01G.S1.02Res. Pos.FP (8IQ6)- (8IQ6)--------------------------ARFASFLERGVPIHSTLHHEMIRAVARFASFLPIHSTERGVLHHEMIRAVSLVREYKILFHVNLNGQ

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.