FP receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IQ6

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41467-023-43922-8

PUBLICATION DATE

Jan. 31, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

55 interactions (Click to see)

LIGANDS

latanoprost (free acid form) - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

PGF2α, PGI2, PGD2, thromboxane A2, PGE2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 A 64 2x37 G.H5 E 390 G.H5.22
Hydrophobic TM6 E 246 6x32 G.H5 N 392 G.H5.24
Van-der-waals TM6 E 246 6x32 G.H5 N 392 G.H5.24
Hydrophobic TM3 V 137 3x54 G.H5 Y 391 G.H5.23
Aromatic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic H8 V 311 8x50 G.H5 L 393 G.H5.25
Van-der-waals H8 V 311 8x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 H 244 6x30 G.H5 L 388 G.H5.20
Hydrophobic TM1 A 54 1x60 G.H5 L 393 G.H5.25
Hydrophobic H8 A 310 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 A 310 8x49 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 137 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 T 145 34x55 G.S1 H 41 G.S1.02
Hydrophobic TM6 H 243 6x29 G.H5 L 388 G.H5.20
Hydrophobic TM3 V 137 3x54 G.H5 L 384 G.H5.16
Polar TM6 H 243 6x29 G.h4s6 G 355 G.h4s6.11
Aromatic TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 L 67 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 L 67 2x40 G.H5 L 393 G.H5.25
Hydrophobic TM1 F 58 1x64 G.H5 L 393 G.H5.25
Polar ICL1 S 62 - G.H5 E 390 G.H5.22
Hydrophobic TM1 F 58 1x64 G.H5 V 394 G.H5.26
Van-der-waals TM1 F 58 1x64 G.H5 V 394 G.H5.26
Polar TM2 F 66 2x39 G.H5 E 390 G.H5.22
Hydrophobic TM1 F 58 1x64 G.H5 R 389 G.H5.21
Hydrophobic H8 A 310 8x49 G.H5 V 394 G.H5.26
Polar TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 141 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM1 F 58 1x64 G.H5 E 390 G.H5.22
Van-der-waals TM1 F 58 1x64 G.H5 E 390 G.H5.22
Polar ICL2 H 143 34x53 G.H5 Y 391 G.H5.23
Polar TM2 S 65 2x38 G.H5 E 390 G.H5.22
Polar TM6 H 244 6x30 G.H5 Q 385 G.H5.17
Hydrophobic ICL2 I 141 34x51 G.H5 K 380 G.H5.12
Hydrophobic ICL2 P 140 34x50 G.H5 K 380 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 K 380 G.H5.12
Polar TM1 R 57 1x63 G.H5 V 394 G.H5.26
Hydrophobic TM5 L 227 5x63 G.H5 L 388 G.H5.20
Hydrophobic TM7 I 305 7x54 G.H5 L 393 G.H5.25
Polar TM3 G 136 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 N 387 G.H5.19
Hydrophobic ICL2 P 140 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 I 141 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 I 141 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 140 34x50 G.H5 L 384 G.H5.16
Hydrophobic H8 R 308 8x47 G.H5 N 392 G.H5.24
Hydrophobic ICL2 H 143 34x53 G.H5 N 387 G.H5.19
Hydrophobic ICL2 I 141 34x51 G.S3 V 217 G.S3.01
Polar TM6 H 243 6x29 G.H5 N 392 G.H5.24
Van-der-waals TM6 H 243 6x29 G.H5 N 392 G.H5.24
Hydrophobic TM6 H 243 6x29 G.H5 V 394 G.H5.26
Van-der-waals TM6 H 243 6x29 G.H5 V 394 G.H5.26
Hydrophobic TM6 M 247 6x33 G.H5 Y 391 G.H5.23
Van-der-waals TM6 M 247 6x33 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 S 144 34x54 G.H5 I 383 G.H5.15