GIP receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

8ITM

RESOLUTION

3.1 Å

REFERENCE

10.1073/PNAS.2306145120

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

gastric inhibitory polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 R 108 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 108 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 108 2x46 G.H5 Q 390 G.H5.22
Polar ICL2 S 190 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 190 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 R 280 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 280 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 F 284 6x44 G.H5 L 393 G.H5.25
Polar TM3 L 184 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 184 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 184 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 E 176 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 176 3x50 G.H5 Y 391 G.H5.23
Polar TM3 L 183 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 183 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 183 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 184 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 259 5x60 G.H5 L 388 G.H5.20
Hydrophobic ICL2 G 189 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 G 189 - G.hns1 A 39 G.hns1.03
Polar TM3 L 186 3x60 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 256 5x57 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 276 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL4 I 334 - G.H5 E 392 G.H5.24
Hydrophobic TM3 Y 179 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 179 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 G 188 - G.S3 V 217 G.S3.01
Hydrophobic TM3 L 184 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 184 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 187 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 V 187 - G.H5 F 376 G.H5.08
Hydrophobic TM3 L 180 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 180 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 180 3x54 G.H5 L 393 G.H5.25
Polar TM5 K 263 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 263 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 263 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 187 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 187 - G.S3 V 217 G.S3.01
Hydrophobic TM5 K 263 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 260 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 260 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 260 5x61 G.H5 L 393 G.H5.25
Polar TM5 K 263 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 263 5x64 G.H5 R 385 G.H5.17
Ionic TM5 K 263 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 263 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 263 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 263 5x64 G.H5 D 381 G.H5.13
Polar ICL2 S 190 - G.hns1 A 39 G.hns1.03
Hydrophobic TM6 R 280 6x40 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 280 6x40 G.H5 L 393 G.H5.25
Ionic H8 K 336 8x48 G.H5 E 392 G.H5.24
Polar H8 K 336 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 336 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 187 - G.H5 R 380 G.H5.12
Hydrophobic H8 N 335 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 K 263 5x64 G.H5 L 394 G.H5.26
Van-der-waals TM5 K 263 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 260 5x61 G.H5 L 394 G.H5.26
Polar H8 E 337 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 E 337 8x49 G.H5 Q 390 G.H5.22
Aromatic TM2 R 108 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 108 2x46 G.H5 Y 391 G.H5.23