C3a receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8J6D

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.CELL.2023.09.020

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

EP141 peptide agonist - Agonist

PHYSIOLOGICAL LIGANDS

C5a, C3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM6 K 374 6x32 G.H5 Y 354 G.H5.26
Polar ICL3 K 370 - G.h4s6 P 315 G.h4s6.09
Van-der-waals ICL3 K 370 - G.h4s6 P 315 G.h4s6.09
Polar TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 368 - G.H5 Y 354 G.H5.26
Hydrophobic TM5 Y 356 5x58 G.H5 L 353 G.H5.25
Hydrophobic H8 G 439 8x47 G.H5 G 352 G.H5.24
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 N 132 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 132 34x55 G.hns1 K 32 G.hns1.03
Polar ICL3 K 370 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 Q 131 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 Q 131 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 Q 131 34x54 G.S3 L 195 G.S3.01
Hydrophobic ICL3 F 368 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 359 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 359 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 371 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM5 R 362 5x64 G.H5 I 344 G.H5.16
Polar ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 368 - G.H5 A 345 G.H5.17
Hydrophobic TM3 V 124 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 368 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 128 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 V 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 378 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 378 6x36 G.H5 L 353 G.H5.25
Polar ICL2 Q 131 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 N 57 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 368 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 F 368 - G.H5 I 344 G.H5.16
Polar ICL2 N 132 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM5 I 359 5x61 G.H5 L 348 G.H5.20