succinate receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JPP

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-024-00968-7

PUBLICATION DATE

May 22, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

9 interactions (Click to see)

LIGANDS

succinic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

succinic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 F 296 7x54 G.H5 N 382 G.H5.10
Polar ICL3 T 223 - G.S6 C 349 G.S6.01
Van-der-waals ICL3 T 223 - G.S6 C 349 G.S6.01
Hydrophobic H8 H 301 8x49 G.H5 R 379 G.H5.21
Hydrophobic ICL4 D 300 - G.H5 V 384 G.H5.12
Hydrophobic TM3 R 120 3x50 G.H5 L 383 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 383 G.H5.25
Hydrophobic TM5 V 221 5x72 G.S6 Y 350 G.S6.02
Hydrophobic ICL3 A 224 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 A 224 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 P 230 6x33 G.H5 L 383 G.H5.25
Hydrophobic ICL2 P 127 - G.H5 L 374 G.H5.02
Ionic TM5 R 217 5x68 G.H5 D 371 G.H5.13
Polar TM5 R 217 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 R 217 5x68 G.H5 D 371 G.H5.13
Aromatic ICL2 F 128 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 128 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 128 - G.S1 H 41 G.S1.02
Polar TM3 D 119 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 D 119 3x49 G.H5 Y 381 G.H5.23
Polar TM3 R 120 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 I 124 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL2 F 128 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 124 3x54 G.H5 L 374 G.H5.02
Hydrophobic H8 H 301 8x49 G.H5 E 380 G.H5.08
Hydrophobic TM6 P 230 6x33 G.H5 V 384 G.H5.12
Van-der-waals TM6 P 230 6x33 G.H5 V 384 G.H5.12
Hydrophobic TM3 I 123 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 N 377 G.H5.19
Hydrophobic ICL2 P 127 - G.H5 I 373 G.H5.15
Hydrophobic ICL3 T 223 - G.S6 Y 350 G.S6.02
Hydrophobic ICL3 L 227 - G.H5 L 378 G.H5.20
Hydrophobic ICL3 L 227 - G.H5 Q 375 G.H5.03
Van-der-waals ICL3 L 227 - G.H5 Q 375 G.H5.03
Hydrophobic H8 F 302 8x50 G.H5 N 382 G.H5.10
Polar TM7 Y 295 7x53 G.H5 N 382 G.H5.10
Hydrophobic TM7 Y 295 7x53 G.H5 N 382 G.H5.10
Van-der-waals TM7 Y 295 7x53 G.H5 N 382 G.H5.10
Polar ICL2 P 127 - G.H5 N 377 G.H5.19
Van-der-waals ICL2 P 127 - G.H5 N 377 G.H5.19
Aromatic ICL2 F 128 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 F 128 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 F 128 - G.H5 F 366 G.H5.08
Hydrophobic ICL3 T 223 - G.S6 P 351 G.S6.03
Hydrophobic TM6 V 234 6x37 G.H5 L 383 G.H5.25
Hydrophobic ICL2 F 128 - G.s6h5 K 370 G.s6h5.03
Van-der-waals ICL2 F 128 - G.s6h5 K 370 G.s6h5.03
Hydrophobic ICL2 P 127 - G.s6h5 K 370 G.s6h5.03
Van-der-waals ICL2 P 127 - G.s6h5 K 370 G.s6h5.03
Hydrophobic ICL4 G 299 - G.H5 V 384 G.H5.12
Hydrophobic TM5 F 213 5x64 G.H5 L 374 G.H5.02
Hydrophobic TM3 I 123 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 I 123 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM6 P 230 6x33 G.H5 L 378 G.H5.20
Hydrophobic ICL2 F 128 - G.H5 C 369 G.H5.11
Hydrophobic TM5 R 217 5x68 G.H5 L 374 G.H5.02
Hydrophobic TM6 L 233 6x36 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 233 6x36 G.H5 L 383 G.H5.25
Polar ICL2 R 129 - G.H5 Y 381 G.H5.23
Van-der-waals ICL2 R 129 - G.H5 Y 381 G.H5.23
Polar TM2 S 58 2x39 G.H5 Y 381 G.H5.23
Hydrophobic TM2 S 58 2x39 G.H5 Y 381 G.H5.23
Van-der-waals TM2 S 58 2x39 G.H5 Y 381 G.H5.23
Hydrophobic ICL4 G 299 - G.H5 N 382 G.H5.10
Hydrophobic ICL3 L 225 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL2 F 128 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 F 128 - G.H5 I 373 G.H5.15