Y2 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

July 31, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

peptide YY, PYY-(3-36), neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
D13N19C23G24F26G.H5GproteinC3x53S8x48P-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H5GPCR segments:TM3ICL3H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x533x544x405x615x645x655x686x266x296x336x377x568x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.S6.02G.h4s6.09G.S3.01G.HN.48Res. Pos.Y2 (8K6N)- (8K6N)----------------RCIRIKLHYRTLMNSRCIRIKLHYRTLMNSHCLNLRIDKFDGTILY

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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