CCR8 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8KFX

RESOLUTION

3.0 Å

REFERENCE

10.1126/SCIADV.ADJ7500

PUBLICATION DATE

Feb. 7, 2024

3D VIEW

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LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

CHEMBL5268017 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

CCL8, CCL1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM4 T 146 4x38 G.HN E 28 G.HN.52
Polar ICL3 Q 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 Q 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 Q 229 - G.H5 D 341 G.H5.13
Polar ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 V 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Polar ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Ionic TM4 R 148 4x40 G.HN E 28 G.HN.52
Polar TM4 R 148 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 148 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 148 4x40 G.HN E 28 G.HN.52
Polar ICL3 H 231 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 H 231 - G.h4s6 K 317 G.h4s6.11
Hydrophobic TM3 A 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.H5 I 343 G.H5.15
Polar ICL3 C 228 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 C 228 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 C 228 - G.H5 D 341 G.H5.13
Hydrophobic TM6 A 236 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM4 R 148 4x40 G.HN R 24 G.HN.48
Polar TM6 N 232 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 N 232 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 232 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 139 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 139 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL3 H 231 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 H 231 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 H 231 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 H 231 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 H 231 - G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 K 306 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 239 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 239 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 N 232 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 232 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM5 Q 224 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 N 230 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 N 230 - G.H5 K 345 G.H5.17
Hydrophobic TM6 K 235 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 235 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 239 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 240 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 240 6x37 G.H5 L 353 G.H5.25
Ionic ICL3 H 231 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 231 - G.h4s6 E 318 G.h4s6.12
Polar TM3 D 130 3x49 G.H5 C 351 G.H5.23
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 139 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 K 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 142 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 142 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM2 T 70 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 70 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 Q 229 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 229 - G.h4s6 E 318 G.h4s6.12
Polar TM6 A 236 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 236 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 236 6x33 G.H5 L 353 G.H5.25
Polar ICL3 N 230 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 N 230 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 N 230 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 138 34x50 G.H5 I 344 G.H5.16
Polar TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 225 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 225 5x65 G.H5 L 348 G.H5.20
Ionic H8 E 305 8x48 G.H5 K 349 G.H5.21
Polar H8 E 305 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 E 305 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 E 305 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 E 305 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 305 8x48 G.H5 F 354 G.H5.26
Polar TM2 T 70 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 70 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 70 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 139 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 L 194 G.S3.01