GPR161 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8KH4

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41467-023-41654-3

PUBLICATION DATE

Oct. 11, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 133 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 M 133 - G.H5 C 379 G.H5.11
Polar TM3 L 130 3x55 G.H5 Q 384 G.H5.16
Polar TM6 A 268 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 268 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 271 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 137 - G.S3 V 217 G.S3.01
Hydrophobic TM5 A 215 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 215 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 V 129 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 211 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 393 G.H5.25
Polar TM5 K 218 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 218 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 218 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 219 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 219 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 215 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 215 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 214 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM6 T 271 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 271 6x36 G.H5 E 392 G.H5.24
Aromatic TM3 R 125 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 K 267 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 267 6x32 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 133 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 133 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 M 133 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 M 133 - G.S3 V 217 G.S3.01
Polar ICL2 P 136 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 136 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 136 - G.hns1 R 38 G.hns1.02
Ionic H8 R 332 8x51 G.H5 E 392 G.H5.24
Polar H8 R 332 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 R 332 8x51 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 133 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 133 - G.H5 R 380 G.H5.12
Ionic TM5 K 218 5x68 G.H5 D 381 G.H5.13
Polar TM5 K 218 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 218 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 218 5x68 G.H5 D 381 G.H5.13
Polar TM3 V 129 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 129 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 132 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 132 - G.H5 I 383 G.H5.15
Polar ICL2 P 136 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 P 136 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 P 132 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 137 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 M 137 - G.s2s3 K 216 G.s2s3.02
Ionic TM6 K 267 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 132 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 132 - G.H5 R 380 G.H5.12
Polar TM3 A 128 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 128 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 128 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 214 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 215 5x65 G.H5 L 393 G.H5.25
Polar TM5 K 218 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 133 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 M 133 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 132 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 132 - G.H5 H 387 G.H5.19
Hydrophobic TM3 V 129 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 M 133 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 M 133 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 136 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 M 133 - G.S1 H 41 G.S1.02
Hydrophobic TM3 A 128 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 128 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 137 - G.hns1 A 39 G.hns1.03
Hydrophobic TM6 K 267 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 A 268 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL4 W 327 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 W 327 - G.H5 E 392 G.H5.24