Rhodopsin - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Bos taurus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8P12

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Nov. 20, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 135 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 252 6x35 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 252 6x35 G.H5 F 354 G.H5.26
Hydrophobic H8 K 311 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 311 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 R 314 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 314 8x51 G.H5 F 354 G.H5.26
Hydrophobic TM5 A 233 5x68 G.H5 T 340 G.H5.12
Ionic TM4 H 152 4x41 G.HN E 28 G.HN.52
Polar ICL2 R 147 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 147 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 147 - G.hns1 A 31 G.hns1.02
Polar TM5 Q 237 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 Q 237 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM4 N 151 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 N 151 4x40 G.HN R 24 G.HN.48
Polar ICL2 N 145 - G.S3 H 195 G.S3.02
Hydrophobic ICL2 N 145 - G.S3 H 195 G.S3.02
Van-der-waals ICL2 N 145 - G.S3 H 195 G.S3.02
Polar TM5 Q 236 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 Q 236 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 Q 236 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL2 F 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 146 - G.hns1 R 32 G.hns1.03
Polar TM5 Q 236 5x71 G.H5 Q 333 G.H5.05
Van-der-waals TM5 Q 236 5x71 G.H5 Q 333 G.H5.05
Hydrophobic TM7 M 309 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 M 309 7x56 G.H5 L 353 G.H5.25
Polar TM6 T 242 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 242 6x25 G.H5 K 345 G.H5.17
Van-der-waals TM6 T 242 6x25 G.H5 K 345 G.H5.17
Polar H8 R 314 8x51 G.H5 L 353 G.H5.25
Polar ICL2 R 147 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 147 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 147 - G.hns1 R 32 G.hns1.03
Polar TM6 S 240 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 240 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 250 6x33 G.H5 L 348 G.H5.20
Polar H8 K 311 8x48 G.H5 L 353 G.H5.25
Hydrophobic H8 K 311 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 K 311 8x48 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 147 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 147 - G.HN E 28 G.HN.52
Hydrophobic TM6 E 249 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 246 6x29 G.H5 K 345 G.H5.17
Polar TM6 T 243 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 T 243 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 T 243 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 T 242 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM5 Q 237 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 Q 237 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 Q 237 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 K 245 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 245 6x28 G.h4s6 D 315 G.h4s6.09
Polar H8 N 310 8x47 G.H5 C 351 G.H5.23
Polar H8 K 311 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 K 311 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 K 311 8x48 G.H5 G 352 G.H5.24
Polar ICL2 N 145 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 145 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 145 - G.hns1 R 32 G.hns1.03
Polar ICL2 N 145 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 E 249 6x32 G.H5 L 348 G.H5.20
Van-der-waals TM6 E 249 6x32 G.H5 L 348 G.H5.20
Polar TM6 T 242 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 T 242 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 T 242 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 E 249 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 249 6x32 G.H5 F 354 G.H5.26
Polar TM6 T 243 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 253 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 253 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 N 310 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 310 8x47 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 242 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 T 243 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM3 V 139 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 139 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 M 253 6x36 G.H5 C 351 G.H5.23
Van-der-waals TM6 M 253 6x36 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 139 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 139 3x54 G.H5 I 344 G.H5.16