MC4 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8QJ2

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Sept. 25, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

55 interactions (Click to see)

LIGANDS

pN162 - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

γ-MSH, agouti-related protein, β-MSH, α-MSH, ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 H 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 222 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 M 215 5x61 G.H5 Y 391 G.H5.23
Hydrophobic TM6 T 246 6x36 G.H5 L 393 G.H5.25
Polar ICL3 N 240 - G.H5 L 394 G.H5.26
Polar TM6 T 246 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 246 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 155 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 155 - G.H5 R 380 G.H5.12
Hydrophobic TM5 H 222 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 A 219 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 151 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 151 3x54 G.H5 H 387 G.H5.19
Polar TM3 I 151 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 151 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 151 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 F 216 5x62 G.H5 L 393 G.H5.25
Aromatic TM3 R 147 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 155 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 155 - G.H5 F 376 G.H5.08
Polar TM3 T 150 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 150 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 151 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 151 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 151 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 151 3x54 G.H5 L 388 G.H5.20
Polar TM3 F 152 3x55 G.H5 Q 384 G.H5.16
Hydrophobic TM5 M 215 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 155 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 155 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 155 - G.H5 I 383 G.H5.15
Polar TM6 G 243 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 243 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 243 6x33 G.H5 L 393 G.H5.25
Polar TM6 K 242 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 242 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 A 154 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 154 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 226 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 226 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 I 223 5x69 G.H5 L 394 G.H5.26
Polar TM3 T 150 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 T 150 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 T 150 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 158 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 A 219 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 219 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 154 - G.H5 Q 384 G.H5.16