α1A-adrenoceptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8THL

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41467-023-40524-2

PUBLICATION DATE

Aug. 16, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

33 interactions (Click to see)

LIGANDS

(-)-adrenaline - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, (-)-adrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 269 6x32 G.H5 V 246 G.H5.26
Hydrophobic TM3 V 128 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 128 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 135 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 132 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 131 - G.H5 L 236 G.H5.16
Van-der-waals ICL2 P 131 - G.H5 L 236 G.H5.16
Polar ICL1 H 58 12x51 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 131 - G.H5 K 232 G.H5.12
Polar C-term C 328 - G.H5 N 244 G.H5.24
Hydrophobic C-term C 328 - G.H5 N 244 G.H5.24
Van-der-waals C-term C 328 - G.H5 N 244 G.H5.24
Hydrophobic TM5 V 210 5x64 G.H5 L 236 G.H5.16
Polar C-term P 327 - G.H5 N 244 G.H5.24
Van-der-waals C-term P 327 - G.H5 N 244 G.H5.24
Hydrophobic ICL2 T 136 - G.hns1 R 32 G.hns1.03
Polar TM6 T 273 6x36 G.H5 N 244 G.H5.24
Hydrophobic TM6 T 273 6x36 G.H5 N 244 G.H5.24
Ionic ICL2 R 133 - G.s2s3 D 77 G.s2s3.01
Polar ICL2 R 133 - G.s2s3 D 77 G.s2s3.01
Hydrophobic TM5 S 215 5x69 G.H5 V 246 G.H5.26
Van-der-waals TM5 S 215 5x69 G.H5 V 246 G.H5.26
Hydrophobic TM6 T 273 6x36 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 132 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 132 - G.H5 F 228 G.H5.08
Hydrophobic ICL2 P 131 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 131 - G.H5 I 235 G.H5.15
Hydrophobic TM3 V 128 3x54 G.H5 Y 243 G.H5.23
Van-der-waals TM3 V 128 3x54 G.H5 Y 243 G.H5.23
Hydrophobic TM5 E 214 5x68 G.H5 L 236 G.H5.16
Hydrophobic ICL2 L 132 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 L 132 - G.H5 K 232 G.H5.12
Hydrophobic TM6 A 270 6x33 G.H5 V 246 G.H5.26
Van-der-waals TM6 A 270 6x33 G.H5 V 246 G.H5.26
Polar TM3 G 127 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 G 127 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 R 133 - G.H5 F 228 G.H5.08
Hydrophobic TM2 S 59 2x37 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 V 207 5x61 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 132 - G.S3 V 79 G.S3.01
Hydrophobic ICL2 L 132 - G.S3 F 81 G.S3.03
Hydrophobic TM6 A 270 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 A 270 6x33 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 135 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 124 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM5 R 213 5x67 G.H5 L 236 G.H5.16