GPR6 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8TYW

RESOLUTION

3.4 Å

REFERENCE

10.1126/SCISIGNAL.ADO8741

PUBLICATION DATE

Dec. 4, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 255 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM2 M 107 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 107 2x39 G.H5 Y 391 G.H5.23
Polar TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 252 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 Q 262 5x75 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 Q 262 5x75 G.h4s6 T 350 G.h4s6.03
Polar TM5 R 254 5x67 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 173 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 173 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 256 5x69 G.H5 L 394 G.H5.26
Polar H8 Q 334 8x48 G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 A 173 34x50 G.H5 Q 384 G.H5.16
Polar TM6 K 276 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 276 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 276 6x32 G.H5 L 394 G.H5.26
Polar H8 E 335 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 170 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 170 3x54 G.H5 L 388 G.H5.20
Polar TM3 S 169 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 169 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 169 3x53 G.H5 H 387 G.H5.19
Polar TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Polar ICL2 Y 177 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 174 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL3 Q 263 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 I 248 5x61 G.H5 L 393 G.H5.25
Polar TM6 T 280 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 280 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 280 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 255 5x68 G.H5 L 394 G.H5.26
Ionic ICL3 H 264 - G.H4 D 343 G.H4.13
Polar ICL3 H 264 - G.H4 D 343 G.H4.13
Hydrophobic TM5 L 261 5x74 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 L 261 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 Y 177 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 177 34x54 G.hns1 R 38 G.hns1.02
Aromatic TM5 H 255 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 255 5x68 G.H5 R 385 G.H5.17
Polar ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 I 259 5x72 G.H5 L 394 G.H5.26
Polar TM5 Q 262 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 Q 262 5x75 G.S6 C 359 G.S6.01
Hydrophobic ICL2 Y 176 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 175 34x52 G.S3 V 217 G.S3.01
Polar ICL2 Y 177 34x54 G.HN Q 35 G.HN.52
Van-der-waals ICL2 Y 177 34x54 G.HN Q 35 G.HN.52
Hydrophobic TM6 G 277 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 277 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 255 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 T 280 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 Q 262 5x75 G.H4 L 346 G.H4.16
Van-der-waals TM5 Q 262 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM7 R 332 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 332 7x56 G.H5 E 392 G.H5.24
Polar H8 N 333 8x47 G.H5 Q 390 G.H5.22
Polar TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 252 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 252 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 259 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 174 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 174 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 174 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 174 34x51 G.S3 V 217 G.S3.01
Polar TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Ionic TM5 R 254 5x67 G.H5 D 381 G.H5.13