CCR8 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8U1U

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Dec. 20, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

110 interactions (Click to see)

LIGANDS

CCL1 - Agonist

PHYSIOLOGICAL LIGANDS

CCL8, CCL1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 234 - G.H5 I 343 G.H5.15
Hydrophobic H8 K 402 8x49 G.H5 C 351 G.H5.23
Polar TM2 T 166 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 166 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 166 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 234 - G.H5 I 344 G.H5.16
Polar ICL2 L 238 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 238 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 238 - G.hns1 R 32 G.hns1.03
Polar TM3 A 230 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 230 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 230 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM4 T 242 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 R 227 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 227 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 K 402 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 K 402 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 238 - G.S3 L 194 G.S3.01
Ionic ICL2 K 239 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 K 329 - G.H5 L 348 G.H5.20
Polar TM6 A 332 6x33 G.H5 L 353 G.H5.25
Ionic ICL2 R 241 - G.H5 D 350 G.H5.22
Hydrophobic TM6 V 336 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 336 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 238 - G.H5 I 343 G.H5.15
Polar ICL2 R 241 - G.H5 N 347 G.H5.19
Hydrophobic TM6 K 331 6x32 G.H5 L 353 G.H5.25
Hydrophobic H8 K 402 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 K 402 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL2 V 235 - G.S3 L 194 G.S3.01
Hydrophobic TM6 K 331 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 235 - G.H5 T 340 G.H5.12
Hydrophobic TM2 T 166 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 166 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 231 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 227 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 227 3x50 G.H5 C 351 G.H5.23
Ionic ICL3 K 329 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 K 239 - G.hns1 R 32 G.hns1.03
Polar ICL3 H 327 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 H 327 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 H 327 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 235 - G.H5 F 336 G.H5.08
Polar H8 G 400 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 400 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 400 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 335 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 335 6x36 G.H5 L 353 G.H5.25
Polar TM2 S 164 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 164 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 164 2x37 G.H5 D 350 G.H5.22
Polar H8 E 401 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 401 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 401 8x48 G.H5 F 354 G.H5.26
Ionic ICL3 H 327 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 H 327 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 327 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 H 327 - G.h4s6 E 318 G.h4s6.12
Polar H8 K 402 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 402 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 402 8x49 G.H5 D 350 G.H5.22