CXCR4 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8U4O

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41594-024-01397-1

PUBLICATION DATE

March 13, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

47 interactions (Click to see)

LIGANDS

CXC12 - Agonist

PHYSIOLOGICAL LIGANDS

CXCL12α, CXCL12, CXCL12γ, CXCL12φ, CXCL12β, CXCL12δ, CXCL12ε



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 138 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 236 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 F 354 G.H5.26
Hydrophobic H8 G 306 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 138 3x54 G.H5 L 353 G.H5.25
Polar ICL2 R 148 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 148 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 148 - G.H5 C 351 G.H5.23
Hydrophobic TM6 A 237 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 142 - G.H5 I 343 G.H5.15
Polar H8 A 307 8x48 G.H5 F 354 G.H5.26
Polar TM2 T 73 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 73 2x39 G.H5 C 351 G.H5.23
Polar TM6 Q 233 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 K 234 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 141 - G.H5 I 343 G.H5.15
Ionic H8 K 308 8x49 G.H5 D 350 G.H5.22
Polar H8 K 308 8x49 G.H5 D 350 G.H5.22
Ionic TM6 K 234 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 234 6x30 G.H5 D 341 G.H5.13
Polar TM6 T 240 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 234 6x30 G.H5 I 344 G.H5.16
Polar TM3 A 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 237 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 237 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 142 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 T 142 - G.H5 T 340 G.H5.12
Hydrophobic TM6 Q 233 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 233 6x29 G.H5 F 354 G.H5.26
Polar ICL2 Q 145 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 145 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 137 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 137 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 141 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 141 - G.H5 I 344 G.H5.16
Ionic TM4 K 149 4x38 G.HN E 28 G.HN.52
Polar TM4 K 149 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 K 149 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 K 234 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 138 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 T 241 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 241 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 226 5x65 G.H5 L 348 G.H5.20