GPR3 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8U8F

RESOLUTION

3.5 Å

REFERENCE

10.1021/ACS.BIOCHEM.3C00647

PUBLICATION DATE

March 6, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

palmitic acid - Agonist pubchem gtoplig chembl_ligand drugbank pubchem

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 142 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 142 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 219 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 219 5x64 G.H5 L 388 G.H5.20
Polar ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Polar TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 231 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 R 231 5x76 G.h4s6 T 350 G.h4s6.03
Polar TM6 G 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 245 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 141 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 141 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Y 145 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 230 5x75 G.H4 L 346 G.H4.16
Hydrophobic ICL2 A 141 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 142 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM3 L 138 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 138 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 142 34x51 G.H5 C 379 G.H5.11
Polar TM4 S 146 4x35 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 S 146 4x35 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 S 146 4x35 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 220 5x65 G.H5 L 394 G.H5.26
Polar H8 N 301 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 301 8x47 G.H5 Q 390 G.H5.22
Ionic TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Polar TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 220 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 220 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 223 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 223 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 138 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 138 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 249 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 229 5x74 G.hgh4 D 323 G.hgh4.13
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 227 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 227 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 141 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 141 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 H 223 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 230 5x75 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 Q 230 5x75 G.h4s6 T 350 G.h4s6.03
Polar TM5 Q 230 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 Q 230 5x75 G.S6 C 359 G.S6.01
Hydrophobic TM5 I 216 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 216 5x61 G.H5 L 393 G.H5.25
Ionic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 K 244 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM4 E 147 4x36 G.HN Q 35 G.HN.52
Van-der-waals TM4 E 147 4x36 G.HN Q 35 G.HN.52
Hydrophobic ICL2 T 143 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 V 220 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 220 5x65 G.H5 L 393 G.H5.25
Ionic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 381 G.H5.13
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 H 223 5x68 G.H5 L 394 G.H5.26
Polar TM6 T 248 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 248 6x36 G.H5 E 392 G.H5.24
Polar TM5 R 222 5x67 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 222 5x67 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Polar TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 138 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 227 5x72 G.H5 L 394 G.H5.26