OR1F1 - Gs

GPCR CLASS (FAMILY)

Class O2 (tetrapod specific odorant)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

l-Menthol - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM6 A 237 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 237 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 225 5x65 G.H5 L 388 G.H5.20
Polar TM6 T 240 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 130 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 130 - G.H5 F 376 G.H5.08
Hydrophobic TM6 C 241 6x37 G.H5 L 393 G.H5.25
Polar TM3 D 121 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 121 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 225 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 129 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 129 - G.H5 H 387 G.H5.19
Hydrophobic TM3 A 125 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 K 236 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM2 M 59 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 129 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 129 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 126 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 228 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 228 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 126 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 126 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 233 6x29 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 130 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 130 - G.H5 I 383 G.H5.15
Hydrophobic TM6 K 236 6x32 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 130 - G.S1 H 41 G.S1.02
Hydrophobic TM5 I 221 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 129 - G.H5 Q 384 G.H5.16
Polar TM3 A 125 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 125 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 G 233 6x29 G.H5 L 394 G.H5.26
Polar H8 K 294 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 122 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 122 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 129 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 132 - G.H5 H 387 G.H5.19
Polar H8 N 293 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 293 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 293 8x47 G.H5 E 392 G.H5.24