OR4D5 - Gs

GPCR CLASS (FAMILY)

Class O2 (tetrapod specific odorant)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

(2R)-2-methyl-1,3-thiazolidine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 Y 131 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 131 - G.H5 Y 391 G.H5.23
Hydrophobic TM2 M 58 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 58 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 129 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 129 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 132 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 132 - G.hns1 R 38 G.hns1.02
Hydrophobic H8 N 290 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 290 8x47 G.H5 E 392 G.H5.24
Van-der-waals ICL2 P 128 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 227 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 227 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 129 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 376 G.H5.08
Polar H8 E 292 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 E 292 8x49 G.H5 E 392 G.H5.24
Polar TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 129 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 129 - G.H5 R 380 G.H5.12
Hydrophobic TM3 I 125 3x54 G.H5 L 393 G.H5.25
Polar H8 K 291 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 291 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 291 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 128 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 128 - G.H5 R 380 G.H5.12