succinate receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WOG

RESOLUTION

3.0 Å

REFERENCE

10.1016/J.CELREP.2024.114381

PUBLICATION DATE

Sept. 11, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

succinic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

succinic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 227 - G.H5 I 344 G.H5.16
Hydrophobic TM6 V 234 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 227 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 L 227 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 128 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 123 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 227 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 A 224 - G.H5 K 345 G.H5.17
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL3 A 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 P 230 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 F 213 5x64 G.H5 I 344 G.H5.16
Ionic TM5 R 217 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 217 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 217 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 217 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Polar ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 E 130 - G.hns1 R 32 G.hns1.03
Polar ICL3 L 225 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 A 224 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 F 128 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 227 - G.H5 F 354 G.H5.26
Polar ICL2 P 127 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 127 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 127 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 127 - G.H5 I 343 G.H5.15
Hydrophobic TM5 L 214 5x65 G.H5 L 348 G.H5.20
Polar TM6 P 230 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 230 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 230 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 230 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 F 128 - G.H5 I 343 G.H5.15
Hydrophobic TM6 L 233 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 H 301 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 H 301 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM5 R 217 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 217 5x68 G.H5 I 344 G.H5.16