MCH2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WST

RESOLUTION

2.4 Å

REFERENCE

10.1038/S41421-024-00679-8

PUBLICATION DATE

June 19, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

pro-MCH - Agonist

PHYSIOLOGICAL LIGANDS

melanin-concentrating hormone



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 P 68 2x39 G.H5 E 242 G.H5.22
Hydrophobic ICL2 F 139 - G.S3 V 79 G.S3.01
Hydrophobic TM4 T 146 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 146 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 Y 223 5x64 G.H5 L 236 G.H5.16
Hydrophobic TM6 L 249 6x33 G.H5 V 246 G.H5.26
Hydrophobic ICL3 N 238 - G.H4 K 195 G.H4.13
Van-der-waals ICL3 N 238 - G.H4 K 195 G.H4.13
Polar ICL4 G 311 - G.H5 N 244 G.H5.24
Hydrophobic TM6 V 253 6x37 G.H5 L 245 G.H5.25
Hydrophobic ICL3 N 238 - G.H4 V 198 G.H4.16
Hydrophobic ICL3 C 237 - G.H4 V 198 G.H4.16
Van-der-waals ICL3 C 237 - G.H4 V 198 G.H4.16
Hydrophobic ICL2 F 139 - G.S1 L 34 G.S1.02
Polar TM5 N 231 5x72 G.H5 D 233 G.H5.13
Hydrophobic TM5 N 231 5x72 G.H5 D 233 G.H5.13
Van-der-waals TM5 N 231 5x72 G.H5 D 233 G.H5.13
Hydrophobic TM2 P 68 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 P 68 2x39 G.H5 Y 243 G.H5.23
Polar ICL2 T 142 - G.HN E 28 G.HN.52
Hydrophobic ICL2 T 142 - G.HN E 28 G.HN.52
Van-der-waals ICL2 T 142 - G.HN E 28 G.HN.52
Polar TM5 Y 223 5x64 G.H5 K 232 G.H5.12
Hydrophobic TM5 Y 223 5x64 G.H5 K 232 G.H5.12
Van-der-waals TM5 Y 223 5x64 G.H5 K 232 G.H5.12
Hydrophobic TM6 M 252 6x36 G.H5 N 244 G.H5.24
Polar ICL3 N 238 - G.H4 R 194 G.H4.12
Hydrophobic TM6 L 249 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 249 6x33 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 138 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 235 G.H5.15
Hydrophobic TM6 M 252 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM6 M 252 6x36 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 139 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 F 139 - G.H5 I 235 G.H5.15
Hydrophobic TM5 M 227 5x68 G.H5 L 236 G.H5.16
Van-der-waals TM5 M 227 5x68 G.H5 L 236 G.H5.16
Polar ICL3 D 233 - G.H4 R 194 G.H4.12
Van-der-waals ICL3 D 233 - G.H4 R 194 G.H4.12
Hydrophobic ICL3 A 234 - G.S6 P 213 G.S6.03
Van-der-waals ICL3 A 234 - G.S6 P 213 G.S6.03
Polar TM3 A 134 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 L 135 3x54 G.H5 N 239 G.H5.19
Van-der-waals TM3 L 135 3x54 G.H5 N 239 G.H5.19
Van-der-waals ICL4 S 310 - G.H5 N 244 G.H5.24
Hydrophobic TM5 M 227 5x68 G.H5 K 232 G.H5.12
Polar TM5 Q 230 5x71 G.H5 N 229 G.H5.09
Hydrophobic TM5 Q 230 5x71 G.H5 N 229 G.H5.09
Van-der-waals ICL2 R 143 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 L 135 3x54 G.H5 L 245 G.H5.25
Van-der-waals TM3 L 135 3x54 G.H5 L 245 G.H5.25
Hydrophobic ICL2 T 142 - G.hns1 R 31 G.hns1.02
Polar ICL3 C 237 - G.H4 R 194 G.H4.12
Hydrophobic ICL3 C 237 - G.H4 R 194 G.H4.12
Van-der-waals ICL3 C 237 - G.H4 R 194 G.H4.12
Polar ICL2 R 143 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 143 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 143 - G.HN E 28 G.HN.52
Hydrophobic TM3 L 135 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL3 A 234 - G.S6 H 214 G.S6.04
Polar TM3 D 130 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 A 134 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL3 C 237 - G.H4 Y 191 G.H4.09
Hydrophobic ICL3 A 234 - G.S6 Y 212 G.S6.02
Hydrophobic ICL2 F 139 - G.H5 K 232 G.H5.12
Hydrophobic TM5 M 227 5x68 G.H5 D 233 G.H5.13
Van-der-waals TM5 M 227 5x68 G.H5 D 233 G.H5.13
Van-der-waals TM6 M 252 6x36 G.H5 Y 243 G.H5.23
Polar TM7 Y 306 7x53 G.H5 N 244 G.H5.24
Hydrophobic TM3 L 135 3x54 G.H5 L 236 G.H5.16
Hydrophobic TM3 R 131 3x50 G.H5 L 245 G.H5.25