A3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

April 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Cl-IB-MECA - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Ionic TM4 H 124 4x39 G.HN E 28 G.HN.52
Polar TM4 H 124 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 H 124 4x39 G.HN E 28 G.HN.52
Hydrophobic TM5 K 207 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 207 5x68 G.H5 I 344 G.H5.16
Van-der-waals H8 K 287 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 200 5x61 G.H5 L 353 G.H5.25
Ionic TM5 K 207 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 207 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 V 116 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 116 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 V 116 - G.H5 T 340 G.H5.12
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 47 2x39 G.H5 C 351 G.H5.23
Polar TM2 T 45 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 45 2x37 G.H5 D 350 G.H5.22
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic H8 I 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 120 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 K 287 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM6 R 224 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 224 6x29 G.H5 F 354 G.H5.26
Hydrophobic H8 I 286 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 108 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 207 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 116 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 115 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 115 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 232 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 204 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 204 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20