GPR34 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XBE

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41467-024-45046-Z

PUBLICATION DATE

May 15, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

CHEMBL4782438 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 K 155 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 P 256 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 P 256 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 K 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 264 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 260 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 I 166 - G.HN E 28 G.HN.52
Van-der-waals ICL2 I 166 - G.HN E 28 G.HN.52
Hydrophobic ICL3 K 254 - G.H5 A 338 G.H5.10
Hydrophobic ICL2 K 164 - G.hns1 A 31 G.hns1.02
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 I 89 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 89 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Q 161 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 161 - G.H5 I 343 G.H5.15
Hydrophobic TM6 V 271 6x41 G.H5 L 353 G.H5.25
Ionic H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Polar H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Polar ICL3 N 257 - G.S6 Y 320 G.S6.02
Polar H8 S 332 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 S 332 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 332 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Ionic ICL3 K 254 - G.H5 D 341 G.H5.13
Polar ICL3 K 254 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 254 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 254 - G.H5 D 341 G.H5.13
Hydrophobic TM7 M 330 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 M 330 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 156 3x54 G.H5 C 351 G.H5.23
Van-der-waals ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic H8 S 331 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 164 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 164 - G.HN E 28 G.HN.52
Hydrophobic TM6 T 264 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Ionic TM6 K 260 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 260 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 260 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL3 P 256 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 256 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 T 264 6x34 G.H5 L 353 G.H5.25
Polar ICL3 K 254 - G.S6 Y 320 G.S6.02
Aromatic ICL3 K 254 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 K 254 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 254 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Van-der-waals TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM6 S 268 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM7 M 330 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 M 330 7x56 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Q 161 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 161 - G.hns1 R 32 G.hns1.03
Polar H8 S 331 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 331 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 G 352 G.H5.24
Aromatic H8 R 335 8x51 G.H5 F 354 G.H5.26
Polar TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 267 6x37 G.H5 L 353 G.H5.25
Polar TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 Y 261 6x31 G.H5 D 341 G.H5.13