GPR34 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XBH

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Dec. 27, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

59 interactions (Click to see)

LIGANDS

CHEMBL4758243 - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 K 254 - G.S6 Y 320 G.S6.02
Aromatic ICL3 K 254 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 K 254 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 254 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 264 6x34 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 264 6x34 G.H5 F 354 G.H5.26
Polar TM2 N 87 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 87 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 P 256 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 256 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 156 3x54 G.H5 L 353 G.H5.25
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 245 5x65 G.H5 L 348 G.H5.20
Polar ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 P 256 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 268 6x38 G.H5 L 353 G.H5.25
Hydrophobic H8 S 332 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 332 8x48 G.H5 F 354 G.H5.26
Ionic ICL2 K 164 - G.HN E 28 G.HN.52
Polar ICL2 K 164 - G.HN E 28 G.HN.52
Polar ICL2 S 159 - G.H5 N 347 G.H5.19
Hydrophobic TM6 K 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM7 M 330 7x56 G.H5 F 354 G.H5.26
Ionic H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 K 336 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM7 M 330 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM2 I 89 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 89 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 264 6x34 G.H5 L 353 G.H5.25
Polar TM3 K 155 3x53 G.H5 N 347 G.H5.19
Polar TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 267 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 S 253 - G.H5 D 337 G.H5.09
Hydrophobic H8 S 331 8x47 G.H5 F 354 G.H5.26
Ionic ICL3 K 254 - G.H5 D 341 G.H5.13
Polar ICL3 K 254 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 254 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 254 - G.H5 D 341 G.H5.13
Van-der-waals ICL2 Q 161 - G.H5 N 347 G.H5.19
Polar ICL3 K 254 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 K 254 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 K 254 - G.H5 A 338 G.H5.10
Hydrophobic TM5 I 248 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 241 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 160 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 I 160 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Polar TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM7 Y 327 7x53 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 271 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 238 5x58 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 161 - G.H5 I 343 G.H5.15
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Van-der-waals TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Polar ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 N 257 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 156 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 155 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM6 T 264 6x34 G.H5 L 348 G.H5.20