kisspeptin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XGO

RESOLUTION

2.7 Å

REFERENCE

10.1126/SCIADV.ADN7771

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

91 interactions (Click to see)

LIGANDS

TAK448 - Agonist

PHYSIOLOGICAL LIGANDS

kisspeptin-10, kisspeptin-54, kisspeptin-52, kisspeptin-14, kisspeptin-13



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 S 243 5x77 G.H4 L 304 G.H4.12
Van-der-waals TM5 S 243 5x77 G.H4 L 304 G.H4.12
Aromatic ICL2 H 152 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 152 - G.hns1 R 32 G.hns1.03
Polar TM2 N 78 2x40 G.H5 E 349 G.H5.22
Hydrophobic ICL2 L 148 - G.S1 L 34 G.S1.02
Hydrophobic H8 H 329 8x49 G.H5 K 348 G.H5.21
Van-der-waals H8 H 329 8x49 G.H5 K 348 G.H5.21
Hydrophobic TM6 L 264 6x36 G.H5 L 352 G.H5.25
Van-der-waals TM6 L 264 6x36 G.H5 L 352 G.H5.25
Hydrophobic ICL2 P 147 - G.H5 L 343 G.H5.16
Hydrophobic ICL2 L 148 - G.S3 V 193 G.S3.01
Hydrophobic H8 G 327 8x47 G.H5 V 353 G.H5.26
Polar TM3 D 139 3x49 G.H5 Y 350 G.H5.23
Hydrophobic TM3 D 139 3x49 G.H5 Y 350 G.H5.23
Van-der-waals TM3 D 139 3x49 G.H5 Y 350 G.H5.23
Hydrophobic ICL2 L 151 - G.S3 V 193 G.S3.01
Hydrophobic ICL2 L 148 - G.H5 K 339 G.H5.12
Ionic TM5 D 242 5x76 G.S6 H 321 G.S6.04
Polar TM5 D 242 5x76 G.S6 H 321 G.S6.04
Hydrophobic TM5 D 242 5x76 G.S6 H 321 G.S6.04
Van-der-waals TM5 D 242 5x76 G.S6 H 321 G.S6.04
Polar TM4 T 155 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM4 T 155 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 155 4x38 G.hns1 R 31 G.hns1.02
Polar TM2 T 77 2x39 G.H5 E 349 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 E 349 G.H5.22
Hydrophobic TM5 Q 246 5x80 G.H4 V 308 G.H4.16
Van-der-waals TM5 Q 246 5x80 G.H4 V 308 G.H4.16
Hydrophobic TM5 S 243 5x77 G.S6 F 322 G.S6.05
Hydrophobic TM5 L 231 5x65 G.H5 L 343 G.H5.16
Hydrophobic ICL2 P 147 - G.H5 I 342 G.H5.15
Van-der-waals ICL2 P 147 - G.H5 I 342 G.H5.15
Hydrophobic ICL2 L 148 - G.H5 F 335 G.H5.08
Van-der-waals ICL2 L 148 - G.H5 F 335 G.H5.08
Hydrophobic TM5 P 240 5x74 G.S6 Y 319 G.S6.02
Hydrophobic TM5 P 240 5x74 G.H5 F 333 G.H5.06
Van-der-waals TM5 P 240 5x74 G.H5 F 333 G.H5.06
Polar TM3 R 140 3x50 G.H5 Y 350 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 350 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 350 G.H5.23
Polar TM6 R 253 6x25 G.H5 Q 344 G.H5.17
Hydrophobic TM6 R 253 6x25 G.H5 Q 344 G.H5.17
Van-der-waals TM6 R 253 6x25 G.H5 Q 344 G.H5.17
Hydrophobic TM6 V 249 6x21 G.h4s6 I 317 G.h4s6.20
Van-der-waals TM6 V 249 6x21 G.h4s6 I 317 G.h4s6.20
Polar ICL2 R 154 - G.H5 Y 350 G.H5.23
Hydrophobic TM3 M 136 3x46 G.H5 Y 350 G.H5.23
Van-der-waals TM3 M 136 3x46 G.H5 Y 350 G.H5.23
Polar TM6 R 253 6x25 G.h4s6 D 315 G.h4s6.12
Hydrophobic TM3 V 143 3x53 G.H5 Y 350 G.H5.23
Van-der-waals TM3 V 143 3x53 G.H5 Y 350 G.H5.23
Hydrophobic ICL2 P 147 - G.H5 K 339 G.H5.12
Polar ICL2 P 147 - G.H5 N 346 G.H5.19
Polar TM3 V 143 3x53 G.H5 N 346 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 346 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 346 G.H5.19
Hydrophobic TM5 M 227 5x61 G.H5 L 352 G.H5.25
Hydrophobic TM5 Q 246 5x80 G.H4 L 304 G.H4.12
Polar TM2 T 77 2x39 G.H5 Y 350 G.H5.23
Hydrophobic TM2 T 77 2x39 G.H5 Y 350 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 Y 350 G.H5.23
Hydrophobic TM5 L 231 5x65 G.H5 L 347 G.H5.20
Polar TM7 A 324 7x54 G.H5 N 351 G.H5.24
Hydrophobic TM7 A 324 7x54 G.H5 N 351 G.H5.24
Van-der-waals TM7 A 324 7x54 G.H5 N 351 G.H5.24
Hydrophobic ICL2 L 151 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 L 151 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 L 148 - G.H5 I 342 G.H5.15
Hydrophobic TM3 T 144 3x54 G.H5 L 343 G.H5.16
Van-der-waals TM3 T 144 3x54 G.H5 L 343 G.H5.16
Hydrophobic TM6 L 264 6x36 G.H5 N 351 G.H5.24
Van-der-waals TM6 L 264 6x36 G.H5 N 351 G.H5.24
Polar ICL2 H 152 - G.s2s3 S 192 G.s2s3.02
Hydrophobic ICL2 H 152 - G.s2s3 S 192 G.s2s3.02
Van-der-waals ICL2 H 152 - G.s2s3 S 192 G.s2s3.02
Hydrophobic TM3 R 140 3x50 G.H5 L 352 G.H5.25
Hydrophobic TM6 V 261 6x33 G.H5 L 352 G.H5.25
Hydrophobic TM6 L 250 6x22 G.S6 Y 319 G.S6.02
Hydrophobic H8 G 327 8x47 G.H5 N 351 G.H5.24
Van-der-waals H8 G 327 8x47 G.H5 N 351 G.H5.24
Hydrophobic TM6 V 261 6x33 G.H5 V 353 G.H5.26
Polar H8 F 330 8x50 G.H5 N 351 G.H5.24
Hydrophobic H8 F 330 8x50 G.H5 N 351 G.H5.24
Polar TM2 T 75 2x37 G.H5 E 349 G.H5.22
Hydrophobic TM2 T 75 2x37 G.H5 E 349 G.H5.22
Van-der-waals TM2 T 75 2x37 G.H5 E 349 G.H5.22
Hydrophobic ICL2 H 152 - G.S3 V 193 G.S3.01
Hydrophobic H8 H 329 8x49 G.H5 E 349 G.H5.22
Hydrophobic TM4 P 156 4x39 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 P 156 4x39 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 L 250 6x22 G.h4s6 I 317 G.h4s6.20
Van-der-waals TM6 L 250 6x22 G.h4s6 I 317 G.h4s6.20
Polar TM7 Y 323 7x53 G.H5 N 351 G.H5.24
Van-der-waals TM7 Y 323 7x53 G.H5 N 351 G.H5.24
Polar TM5 D 242 5x76 G.S6 F 322 G.S6.05
Hydrophobic TM5 D 242 5x76 G.S6 F 322 G.S6.05
Van-der-waals TM5 D 242 5x76 G.S6 F 322 G.S6.05
Van-der-waals TM3 T 144 3x54 G.H5 L 347 G.H5.20
Hydrophobic TM6 V 261 6x33 G.H5 L 347 G.H5.20
Polar TM5 S 243 5x77 G.H4 E 301 G.H4.09
Hydrophobic TM5 S 243 5x77 G.H4 E 301 G.H4.09
Van-der-waals TM5 S 243 5x77 G.H4 E 301 G.H4.09
Hydrophobic TM6 R 253 6x25 G.h4s6 I 317 G.h4s6.20
Hydrophobic TM6 K 260 6x32 G.H5 V 353 G.H5.26