GproteinDb

kisspeptin receptor - G_q

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XGO

RESOLUTION

2.7 Å

REFERENCE

10.1126/SCIADV.ADN7771

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

91 interactions (Click to see)

LIGANDS

TAK448 - Agonist

PHYSIOLOGICAL LIGANDS

kisspeptin-10, kisspeptin-54, kisspeptin-52, kisspeptin-14, kisspeptin-13

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	ICL2	H	152	-	G.hns1	R	32	G.hns1.03
Hydrophobic	TM5	S	243	5x77	G.H4	L	304	G.H4.12
Hydrophobic	ICL2	H	152	-	G.hns1	R	32	G.hns1.03
Hydrophobic	ICL2	L	148	-	G.S1	L	34	G.S1.02
Hydrophobic	H8	H	329	8x49	G.H5	K	348	G.H5.21
Hydrophobic	TM6	L	264	6x36	G.H5	L	352	G.H5.25
Hydrophobic	ICL2	P	147	-	G.H5	L	343	G.H5.16
Hydrophobic	ICL2	L	148	-	G.S3	V	193	G.S3.01
Hydrophobic	H8	G	327	8x47	G.H5	V	353	G.H5.26
Hydrophobic	TM3	D	139	3x49	G.H5	Y	350	G.H5.23
Hydrophobic	ICL2	L	151	-	G.S3	V	193	G.S3.01
Hydrophobic	ICL2	L	148	-	G.H5	K	339	G.H5.12
Hydrophobic	TM5	D	242	5x76	G.S6	H	321	G.S6.04
Hydrophobic	TM4	T	155	4x38	G.hns1	R	31	G.hns1.02
Hydrophobic	TM2	T	77	2x39	G.H5	E	349	G.H5.22
Hydrophobic	TM5	Q	246	5x80	G.H4	V	308	G.H4.16
Hydrophobic	TM5	S	243	5x77	G.S6	F	322	G.S6.05
Hydrophobic	TM5	L	231	5x65	G.H5	L	343	G.H5.16
Hydrophobic	ICL2	P	147	-	G.H5	I	342	G.H5.15
Hydrophobic	ICL2	L	148	-	G.H5	F	335	G.H5.08
Hydrophobic	TM5	P	240	5x74	G.S6	Y	319	G.S6.02
Hydrophobic	TM5	P	240	5x74	G.H5	F	333	G.H5.06
Hydrophobic	TM3	R	140	3x50	G.H5	Y	350	G.H5.23
Hydrophobic	TM6	R	253	6x25	G.H5	Q	344	G.H5.17
Hydrophobic	TM6	V	249	6x21	G.h4s6	I	317	G.h4s6.20
Hydrophobic	TM3	M	136	3x46	G.H5	Y	350	G.H5.23
Hydrophobic	TM3	V	143	3x53	G.H5	Y	350	G.H5.23
Hydrophobic	ICL2	P	147	-	G.H5	K	339	G.H5.12
Hydrophobic	TM3	V	143	3x53	G.H5	N	346	G.H5.19
Hydrophobic	TM5	M	227	5x61	G.H5	L	352	G.H5.25
Hydrophobic	TM5	Q	246	5x80	G.H4	L	304	G.H4.12
Hydrophobic	TM2	T	77	2x39	G.H5	Y	350	G.H5.23
Hydrophobic	TM5	L	231	5x65	G.H5	L	347	G.H5.20
Hydrophobic	TM7	A	324	7x54	G.H5	N	351	G.H5.24
Hydrophobic	ICL2	L	151	-	G.S1	L	34	G.S1.02
Hydrophobic	ICL2	L	148	-	G.H5	I	342	G.H5.15
Hydrophobic	TM3	T	144	3x54	G.H5	L	343	G.H5.16
Hydrophobic	TM6	L	264	6x36	G.H5	N	351	G.H5.24
Hydrophobic	ICL2	H	152	-	G.s2s3	S	192	G.s2s3.02
Hydrophobic	TM3	R	140	3x50	G.H5	L	352	G.H5.25
Hydrophobic	TM6	V	261	6x33	G.H5	L	352	G.H5.25
Hydrophobic	TM6	L	250	6x22	G.S6	Y	319	G.S6.02
Hydrophobic	H8	G	327	8x47	G.H5	N	351	G.H5.24
Hydrophobic	TM6	V	261	6x33	G.H5	V	353	G.H5.26
Hydrophobic	H8	F	330	8x50	G.H5	N	351	G.H5.24
Hydrophobic	TM2	T	75	2x37	G.H5	E	349	G.H5.22
Hydrophobic	ICL2	H	152	-	G.S3	V	193	G.S3.01
Hydrophobic	H8	H	329	8x49	G.H5	E	349	G.H5.22
Hydrophobic	TM4	P	156	4x39	G.hns1	R	31	G.hns1.02
Hydrophobic	TM6	L	250	6x22	G.h4s6	I	317	G.h4s6.20
Hydrophobic	TM5	D	242	5x76	G.S6	F	322	G.S6.05
Hydrophobic	TM6	V	261	6x33	G.H5	L	347	G.H5.20
Hydrophobic	TM5	S	243	5x77	G.H4	E	301	G.H4.09
Hydrophobic	TM6	R	253	6x25	G.h4s6	I	317	G.h4s6.20
Hydrophobic	TM6	K	260	6x32	G.H5	V	353	G.H5.26
Ionic	TM5	D	242	5x76	G.S6	H	321	G.S6.04
Polar	TM2	N	78	2x40	G.H5	E	349	G.H5.22
Polar	TM3	D	139	3x49	G.H5	Y	350	G.H5.23
Polar	TM5	D	242	5x76	G.S6	H	321	G.S6.04
Polar	TM4	T	155	4x38	G.hns1	R	31	G.hns1.02
Polar	TM2	T	77	2x39	G.H5	E	349	G.H5.22
Polar	TM3	R	140	3x50	G.H5	Y	350	G.H5.23
Polar	TM6	R	253	6x25	G.H5	Q	344	G.H5.17
Polar	ICL2	R	154	-	G.H5	Y	350	G.H5.23
Polar	TM6	R	253	6x25	G.h4s6	D	315	G.h4s6.12
Polar	ICL2	P	147	-	G.H5	N	346	G.H5.19
Polar	TM3	V	143	3x53	G.H5	N	346	G.H5.19
Polar	TM2	T	77	2x39	G.H5	Y	350	G.H5.23
Polar	TM7	A	324	7x54	G.H5	N	351	G.H5.24
Polar	ICL2	H	152	-	G.s2s3	S	192	G.s2s3.02
Polar	H8	F	330	8x50	G.H5	N	351	G.H5.24
Polar	TM2	T	75	2x37	G.H5	E	349	G.H5.22
Polar	TM7	Y	323	7x53	G.H5	N	351	G.H5.24
Polar	TM5	D	242	5x76	G.S6	F	322	G.S6.05
Polar	TM5	S	243	5x77	G.H4	E	301	G.H4.09
Van-der-waals	TM5	S	243	5x77	G.H4	L	304	G.H4.12
Van-der-waals	H8	H	329	8x49	G.H5	K	348	G.H5.21
Van-der-waals	TM6	L	264	6x36	G.H5	L	352	G.H5.25
Van-der-waals	TM3	D	139	3x49	G.H5	Y	350	G.H5.23
Van-der-waals	TM5	D	242	5x76	G.S6	H	321	G.S6.04
Van-der-waals	TM4	T	155	4x38	G.hns1	R	31	G.hns1.02
Van-der-waals	TM5	Q	246	5x80	G.H4	V	308	G.H4.16
Van-der-waals	ICL2	P	147	-	G.H5	I	342	G.H5.15
Van-der-waals	ICL2	L	148	-	G.H5	F	335	G.H5.08
Van-der-waals	TM5	P	240	5x74	G.H5	F	333	G.H5.06
Van-der-waals	TM3	R	140	3x50	G.H5	Y	350	G.H5.23
Van-der-waals	TM6	R	253	6x25	G.H5	Q	344	G.H5.17
Van-der-waals	TM6	V	249	6x21	G.h4s6	I	317	G.h4s6.20
Van-der-waals	TM3	M	136	3x46	G.H5	Y	350	G.H5.23
Van-der-waals	TM3	V	143	3x53	G.H5	Y	350	G.H5.23
Van-der-waals	TM3	V	143	3x53	G.H5	N	346	G.H5.19
Van-der-waals	TM2	T	77	2x39	G.H5	Y	350	G.H5.23
Van-der-waals	TM7	A	324	7x54	G.H5	N	351	G.H5.24
Van-der-waals	ICL2	L	151	-	G.S1	L	34	G.S1.02
Van-der-waals	TM3	T	144	3x54	G.H5	L	343	G.H5.16
Van-der-waals	TM6	L	264	6x36	G.H5	N	351	G.H5.24
Van-der-waals	ICL2	H	152	-	G.s2s3	S	192	G.s2s3.02
Van-der-waals	H8	G	327	8x47	G.H5	N	351	G.H5.24
Van-der-waals	TM2	T	75	2x37	G.H5	E	349	G.H5.22
Van-der-waals	TM4	P	156	4x39	G.hns1	R	31	G.hns1.02
Van-der-waals	TM6	L	250	6x22	G.h4s6	I	317	G.h4s6.20
Van-der-waals	TM7	Y	323	7x53	G.H5	N	351	G.H5.24
Van-der-waals	TM5	D	242	5x76	G.S6	F	322	G.S6.05
Van-der-waals	TM3	T	144	3x54	G.H5	L	347	G.H5.20
Van-der-waals	TM5	S	243	5x77	G.H4	E	301	G.H4.09

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