SST1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XIO

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

July 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

38 interactions (Click to see)

LIGANDS

(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 158 3x53 G.H5 C 358 G.H5.23
Van-der-waals TM3 A 158 3x53 G.H5 C 358 G.H5.23
Hydrophobic ICL4 D 328 - G.H5 F 361 G.H5.26
Aromatic ICL3 W 259 - G.S6 Y 327 G.S6.02
Hydrophobic ICL3 W 259 - G.S6 Y 327 G.S6.02
Van-der-waals ICL3 W 259 - G.S6 Y 327 G.S6.02
Polar ICL2 A 166 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 166 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 166 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 Y 276 6x40 G.H5 L 360 G.H5.25
Hydrophobic TM5 V 253 5x68 G.H5 I 351 G.H5.16
Polar TM3 A 158 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 162 - G.H5 N 354 G.H5.19
Van-der-waals TM5 A 257 5x72 G.H5 D 345 G.H5.10
Polar ICL2 R 169 - G.H5 C 358 G.H5.23
Hydrophobic ICL2 R 169 - G.H5 C 358 G.H5.23
Van-der-waals ICL2 R 169 - G.H5 C 358 G.H5.23
Hydrophobic ICL2 P 162 - G.H5 I 350 G.H5.15
Hydrophobic TM6 I 269 6x33 G.H5 L 355 G.H5.20
Polar ICL4 S 327 - G.H5 G 359 G.H5.24
Van-der-waals ICL4 S 327 - G.H5 G 359 G.H5.24
Hydrophobic TM6 I 269 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM3 V 159 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 159 3x54 G.H5 L 355 G.H5.20
Van-der-waals ICL3 W 259 - G.H5 K 352 G.H5.17
Hydrophobic TM6 I 269 6x33 G.H5 F 361 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 F 361 G.H5.26
Polar TM5 K 256 5x71 G.H5 N 344 G.H5.09
Hydrophobic TM5 K 256 5x71 G.H5 N 344 G.H5.09
Van-der-waals TM5 K 256 5x71 G.H5 N 344 G.H5.09
Hydrophobic ICL2 R 167 - G.HN Q 28 G.HN.52
Hydrophobic TM5 A 257 5x72 G.H5 N 344 G.H5.09
Hydrophobic TM5 V 253 5x68 G.H5 T 347 G.H5.12
Hydrophobic TM5 M 250 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 M 250 5x65 G.H5 L 355 G.H5.20
Polar ICL3 W 259 - G.H5 D 348 G.H5.13
Hydrophobic ICL3 W 259 - G.H5 D 348 G.H5.13
Hydrophobic TM3 V 159 3x54 G.H5 N 354 G.H5.19
Hydrophobic TM3 R 155 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 155 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM5 V 253 5x68 G.H5 D 348 G.H5.13
Van-der-waals TM5 V 253 5x68 G.H5 D 348 G.H5.13
Hydrophobic ICL4 N 329 - G.H5 G 359 G.H5.24
Hydrophobic TM5 I 246 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM3 V 159 3x54 G.H5 I 351 G.H5.16
Van-der-waals TM3 V 159 3x54 G.H5 I 351 G.H5.16