SST1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

004-DTR-LYS-TY5-PHE-A1D5E - Agonist

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 Y 243 5x58 G.H5 L 360 G.H5.25
Van-der-waals TM5 Y 243 5x58 G.H5 L 360 G.H5.25
Hydrophobic TM3 A 158 3x53 G.H5 C 358 G.H5.23
Van-der-waals H8 D 328 8x48 G.H5 G 359 G.H5.24
Hydrophobic H8 D 328 8x48 G.H5 F 361 G.H5.26
Van-der-waals H8 D 328 8x48 G.H5 F 361 G.H5.26
Polar H8 N 329 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 N 329 8x49 G.H5 R 356 G.H5.21
Aromatic ICL3 W 259 - G.S6 Y 327 G.S6.02
Hydrophobic ICL3 W 259 - G.S6 Y 327 G.S6.02
Van-der-waals ICL3 W 259 - G.S6 Y 327 G.S6.02
Hydrophobic TM6 Y 276 6x40 G.H5 L 360 G.H5.25
Hydrophobic TM5 V 253 5x68 G.H5 I 351 G.H5.16
Van-der-waals TM5 V 253 5x68 G.H5 I 351 G.H5.16
Polar TM3 A 158 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 354 G.H5.19
Polar ICL2 R 169 34x57 G.H5 C 358 G.H5.23
Hydrophobic ICL2 R 169 34x57 G.H5 C 358 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 C 358 G.H5.23
Hydrophobic ICL2 P 162 34x50 G.H5 I 350 G.H5.15
Hydrophobic ICL3 K 263 - G.H5 K 352 G.H5.17
Hydrophobic TM6 I 269 6x33 G.H5 L 355 G.H5.20
Polar H8 S 327 8x47 G.H5 G 359 G.H5.24
Hydrophobic H8 S 327 8x47 G.H5 G 359 G.H5.24
Van-der-waals H8 S 327 8x47 G.H5 G 359 G.H5.24
Hydrophobic TM6 I 269 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 360 G.H5.25
Polar TM2 T 93 2x39 G.H5 C 358 G.H5.23
Hydrophobic TM2 T 93 2x39 G.H5 C 358 G.H5.23
Hydrophobic TM6 I 269 6x33 G.H5 F 361 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 F 361 G.H5.26
Polar TM5 K 256 5x71 G.H5 N 344 G.H5.09
Hydrophobic TM5 K 256 5x71 G.H5 N 344 G.H5.09
Van-der-waals TM5 K 256 5x71 G.H5 N 344 G.H5.09
Polar TM3 R 155 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 C 358 G.H5.23
Ionic ICL2 R 169 34x57 G.H5 D 357 G.H5.22
Polar ICL2 R 169 34x57 G.H5 D 357 G.H5.22
Hydrophobic TM5 A 257 5x72 G.H5 N 344 G.H5.09
Van-der-waals TM5 A 257 5x72 G.H5 N 344 G.H5.09
Hydrophobic TM5 V 253 5x68 G.H5 T 347 G.H5.12
Hydrophobic TM5 M 250 5x65 G.H5 L 355 G.H5.20
Polar ICL3 W 259 - G.H5 D 348 G.H5.13
Van-der-waals ICL3 W 259 - G.H5 D 348 G.H5.13
Polar TM6 K 268 6x32 G.H5 F 361 G.H5.26
Aromatic TM6 K 268 6x32 G.H5 F 361 G.H5.26
Hydrophobic TM6 K 268 6x32 G.H5 F 361 G.H5.26
Ionic H8 D 328 8x48 G.h4s6 R 323 G.h4s6.12
Polar H8 D 328 8x48 G.h4s6 R 323 G.h4s6.12
Hydrophobic TM3 V 159 3x54 G.H5 N 354 G.H5.19
Polar H8 N 329 8x49 G.H5 D 357 G.H5.22
Hydrophobic H8 N 329 8x49 G.H5 D 357 G.H5.22
Van-der-waals H8 N 329 8x49 G.H5 D 357 G.H5.22
Hydrophobic TM3 R 155 3x50 G.H5 L 360 G.H5.25
Hydrophobic ICL3 W 259 - G.S6 P 328 G.S6.03
Hydrophobic TM5 V 253 5x68 G.H5 D 348 G.H5.13
Polar H8 N 329 8x49 G.H5 G 359 G.H5.24
Hydrophobic H8 N 329 8x49 G.H5 G 359 G.H5.24
Van-der-waals H8 N 329 8x49 G.H5 G 359 G.H5.24
Hydrophobic TM3 V 159 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 159 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM3 V 159 3x54 G.H5 I 351 G.H5.16
Hydrophobic ICL3 W 259 - G.S6 C 326 G.S6.01
Van-der-waals ICL3 W 259 - G.S6 C 326 G.S6.01