GPER - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XOF

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

April 10, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

N1-(7-Chloroquinolin-4-yl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

17β-estradiol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 R 169 - G.H5 E 390 G.H5.22
Polar ICL2 R 169 - G.H5 E 390 G.H5.22
Van-der-waals ICL2 R 169 - G.H5 E 390 G.H5.22
Hydrophobic ICL2 A 162 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 162 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 R 164 - G.s2s3 K 216 G.s2s3.02
Polar H8 T 330 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 T 330 8x49 G.H5 R 389 G.H5.21
Polar H8 F 331 8x50 G.H5 N 392 G.H5.24
Hydrophobic H8 F 331 8x50 G.H5 N 392 G.H5.24
Van-der-waals H8 F 331 8x50 G.H5 N 392 G.H5.24
Van-der-waals TM2 Y 97 2x42 G.H5 Y 391 G.H5.23
Polar ICL2 R 164 - G.s2s3 D 215 G.s2s3.01
Polar H8 T 330 8x49 G.H5 N 392 G.H5.24
Hydrophobic H8 T 330 8x49 G.H5 N 392 G.H5.24
Van-der-waals H8 T 330 8x49 G.H5 N 392 G.H5.24
Polar TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Polar TM3 A 158 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 387 G.H5.19
Polar TM6 R 254 6x30 G.H5 Q 385 G.H5.17
Hydrophobic TM6 R 254 6x30 G.H5 Q 385 G.H5.17
Van-der-waals TM6 R 254 6x30 G.H5 Q 385 G.H5.17
Hydrophobic ICL2 A 162 - G.H5 N 387 G.H5.19
Van-der-waals ICL2 A 162 - G.H5 N 387 G.H5.19
Hydrophobic ICL3 R 248 - G.S6 Y 360 G.S6.02
Polar TM3 M 151 3x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 M 151 3x46 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 151 3x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 248 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 R 248 - G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 167 - G.HN Q 35 G.HN.52
Polar ICL2 R 169 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 169 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 M 163 - G.S3 V 217 G.S3.01
Hydrophobic TM6 L 250 6x26 G.h4s6 I 358 G.h4s6.20
Hydrophobic ICL2 R 169 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 167 - G.hns1 R 39 G.hns1.03
Polar H8 T 330 8x49 G.H5 V 394 G.H5.26
Van-der-waals H8 T 330 8x49 G.H5 V 394 G.H5.26
Polar H8 E 329 8x48 G.H5 N 392 G.H5.24
Hydrophobic TM6 A 257 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM2 P 94 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 94 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 163 - G.H5 C 379 G.H5.11
Polar TM7 Y 324 7x53 G.H5 N 392 G.H5.24
Van-der-waals TM7 Y 324 7x53 G.H5 N 392 G.H5.24
Hydrophobic TM6 I 261 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 254 6x30 G.H5 L 384 G.H5.16
Van-der-waals TM6 R 254 6x30 G.H5 L 384 G.H5.16
Hydrophobic ICL3 R 248 - G.H5 N 377 G.H5.09
Hydrophobic H8 E 329 8x48 G.H5 V 394 G.H5.26
Hydrophobic ICL2 M 163 - G.H5 I 383 G.H5.15
Hydrophobic TM3 R 155 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 240 5x64 G.H5 L 384 G.H5.16
Ionic TM6 R 253 6x29 G.h4s6 D 354 G.h4s6.10
Polar TM6 R 253 6x29 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM2 F 98 2x43 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 163 - G.H5 K 380 G.H5.12
Ionic TM6 R 254 6x30 G.H5 D 381 G.H5.13
Polar TM6 R 254 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 254 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 254 6x30 G.H5 D 381 G.H5.13
Hydrophobic H8 G 328 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 G 328 8x47 G.H5 N 392 G.H5.24
Polar ICL2 S 166 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 S 166 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 166 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 159 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 159 3x54 G.H5 L 393 G.H5.25
Polar TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 159 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM2 P 94 2x39 G.H5 E 390 G.H5.22
Hydrophobic TM3 L 159 3x54 G.H5 N 387 G.H5.19
Van-der-waals TM3 L 159 3x54 G.H5 N 387 G.H5.19
Hydrophobic ICL2 M 163 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 163 - G.H5 F 376 G.H5.08
Hydrophobic TM3 L 159 3x54 G.H5 L 384 G.H5.16
Hydrophobic TM5 A 244 5x68 G.H5 L 384 G.H5.16
Hydrophobic TM6 R 253 6x29 G.H5 V 394 G.H5.26
Hydrophobic TM5 L 241 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 M 260 6x36 G.H5 L 393 G.H5.25
Polar TM7 S 325 7x54 G.H5 N 392 G.H5.24
Hydrophobic TM7 S 325 7x54 G.H5 N 392 G.H5.24
Van-der-waals TM7 S 325 7x54 G.H5 N 392 G.H5.24
Hydrophobic TM2 F 98 2x43 G.H5 N 392 G.H5.24
Hydrophobic TM3 A 158 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 163 - G.S1 L 41 G.S1.02
Van-der-waals ICL2 M 163 - G.S1 L 41 G.S1.02
Hydrophobic TM6 L 250 6x26 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 L 250 6x26 G.h4s6 G 355 G.h4s6.11
Ionic ICL3 R 248 - G.H5 D 378 G.H5.10
Polar ICL3 R 248 - G.H5 D 378 G.H5.10
Hydrophobic ICL3 R 248 - G.H5 D 378 G.H5.10
Van-der-waals ICL3 R 248 - G.H5 D 378 G.H5.10
Hydrophobic TM6 A 257 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 M 260 6x36 G.H5 N 392 G.H5.24
Van-der-waals TM6 M 260 6x36 G.H5 N 392 G.H5.24
Hydrophobic ICL3 G 249 - G.H5 D 381 G.H5.13
Hydrophobic TM6 A 257 6x33 G.H5 V 394 G.H5.26