PAR1 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XOR

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Sept. 18, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

Tethered agonist - Agonist

PHYSIOLOGICAL LIGANDS

thrombin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 A 137 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 A 137 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 V 204 3x54 G.H5 L 351 G.H5.16
Hydrophobic ICL2 M 208 34x51 G.S3 F 196 G.S3.03
Polar ICL2 R 214 34x57 G.H5 N 354 G.H5.19
Hydrophobic TM6 S 306 6x29 G.h4s6 I 325 G.h4s6.20
Van-der-waals TM6 S 306 6x29 G.h4s6 I 325 G.h4s6.20
Hydrophobic ICL2 L 211 34x54 G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 211 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 311 6x34 G.H5 L 355 G.H5.20
Polar TM2 A 137 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 A 137 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 A 137 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM5 L 297 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM3 V 204 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 204 3x54 G.H5 L 355 G.H5.20
Hydrophobic ICL2 M 208 34x51 G.H5 F 343 G.H5.08
Polar TM3 A 203 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 203 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 203 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 S 212 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 212 34x55 G.hns1 R 32 G.hns1.03
Polar TM7 Y 371 7x53 G.H5 N 359 G.H5.24
Van-der-waals TM7 Y 371 7x53 G.H5 N 359 G.H5.24
Hydrophobic TM2 K 135 2x37 G.H5 E 357 G.H5.22
Polar TM2 P 136 2x38 G.H5 E 357 G.H5.22
Hydrophobic TM2 P 136 2x38 G.H5 E 357 G.H5.22
Van-der-waals TM2 M 141 2x43 G.H5 N 359 G.H5.24
Hydrophobic TM6 K 308 6x31 G.H5 L 351 G.H5.16
Van-der-waals TM6 K 308 6x31 G.H5 L 351 G.H5.16
Hydrophobic ICL2 L 211 34x54 G.S1 L 34 G.S1.02
Hydrophobic ICL2 M 208 34x51 G.S1 L 34 G.S1.02
Van-der-waals ICL2 M 208 34x51 G.S1 L 34 G.S1.02
Hydrophobic TM6 R 310 6x33 G.H5 V 361 G.H5.26
Hydrophobic ICL3 V 302 - G.H5 L 351 G.H5.16
Polar TM3 D 199 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 199 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 199 3x49 G.H5 Y 358 G.H5.23
Ionic ICL2 R 214 34x57 G.H5 E 357 G.H5.22
Polar ICL2 R 214 34x57 G.H5 E 357 G.H5.22
Hydrophobic ICL2 R 214 34x57 G.H5 E 357 G.H5.22
Van-der-waals ICL2 R 214 34x57 G.H5 E 357 G.H5.22
Hydrophobic TM6 K 308 6x31 G.H5 L 355 G.H5.20
Hydrophobic TM6 R 305 6x28 G.S6 Y 327 G.S6.02
Hydrophobic TM6 R 305 6x28 G.H5 N 344 G.H5.09
Hydrophobic ICL2 M 208 34x51 G.H5 I 350 G.H5.15
Hydrophobic ICL2 P 207 34x50 G.H5 I 350 G.H5.15
Hydrophobic ICL2 M 208 34x51 G.H5 C 346 G.H5.11
Hydrophobic ICL2 M 208 34x51 G.S3 V 194 G.S3.01
Hydrophobic ICL2 P 207 34x50 G.H5 L 351 G.H5.16
Polar TM6 A 311 6x34 G.H5 L 360 G.H5.25
Hydrophobic TM6 A 311 6x34 G.H5 L 360 G.H5.25
Van-der-waals TM6 A 311 6x34 G.H5 L 360 G.H5.25
Polar H8 S 375 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 S 375 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 S 375 8x47 G.H5 N 359 G.H5.24
Hydrophobic TM3 A 203 3x53 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 207 34x50 G.H5 K 347 G.H5.12
Polar TM6 S 306 6x29 G.H5 D 348 G.H5.13
Hydrophobic TM6 S 306 6x29 G.H5 D 348 G.H5.13
Van-der-waals TM6 S 306 6x29 G.H5 D 348 G.H5.13
Hydrophobic ICL2 M 208 34x51 G.H5 K 347 G.H5.12
Van-der-waals ICL2 M 208 34x51 G.H5 K 347 G.H5.12
Hydrophobic TM6 R 310 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 L 314 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM3 R 200 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 200 3x50 G.H5 L 360 G.H5.25
Polar ICL2 S 210 34x53 G.H5 N 354 G.H5.19
Hydrophobic TM6 R 305 6x28 G.H5 D 348 G.H5.13
Ionic TM6 K 308 6x31 G.H5 D 348 G.H5.13
Polar TM6 K 308 6x31 G.H5 D 348 G.H5.13
Van-der-waals TM6 K 308 6x31 G.H5 D 348 G.H5.13
Hydrophobic TM6 A 311 6x34 G.H5 V 361 G.H5.26
Hydrophobic H8 S 376 8x48 G.H5 V 361 G.H5.26
Van-der-waals H8 S 376 8x48 G.H5 V 361 G.H5.26
Polar TM7 Y 372 7x54 G.H5 N 359 G.H5.24
Hydrophobic TM3 I 196 3x46 G.H5 Y 358 G.H5.23
Hydrophobic TM6 S 306 6x29 G.H5 Q 352 G.H5.17
Van-der-waals TM6 S 306 6x29 G.H5 Q 352 G.H5.17
Polar TM3 R 200 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 200 3x50 G.H5 Y 358 G.H5.23
Polar TM6 S 306 6x29 G.S6 Y 327 G.S6.02
Van-der-waals TM6 S 306 6x29 G.S6 Y 327 G.S6.02
Van-der-waals TM6 K 308 6x31 G.H5 Q 352 G.H5.17