TAS2R14 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XQP

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-024-07569-9

PUBLICATION DATE

July 10, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

28 interactions (Click to see)

LIGANDS

aristolochic acid - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 348 G.H5.20
Ionic TM4 R 125 4x37 G.HN E 43 G.HN.52
Polar TM4 R 125 4x37 G.HN E 43 G.HN.52
Van-der-waals TM4 R 125 4x37 G.HN E 43 G.HN.52
Hydrophobic TM5 H 208 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 208 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 216 - G.S6 Y 320 G.S6.02
Polar ICL3 S 223 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 S 223 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 S 223 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 N 113 - G.H5 I 344 G.H5.16
Hydrophobic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 111 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 111 3x54 G.H5 I 344 G.H5.16
Polar TM5 T 215 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 T 215 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 T 215 5x75 G.H5 D 337 G.H5.09
Hydrophobic ICL3 A 226 - G.H5 F 354 G.H5.26
Hydrophobic H8 K 285 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 285 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 227 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 H 227 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 227 6x32 G.H5 L 348 G.H5.20
Van-der-waals TM6 H 227 6x32 G.H5 L 348 G.H5.20
Polar TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM7 G 283 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 212 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 212 5x72 G.H5 D 337 G.H5.09
Polar ICL2 W 124 - G.HN E 43 G.HN.52
Hydrophobic ICL2 W 124 - G.HN E 43 G.HN.52
Van-der-waals ICL2 W 124 - G.HN E 43 G.HN.52
Hydrophobic TM3 I 111 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 111 3x54 G.H5 N 347 G.H5.19
Ionic TM4 R 125 4x37 G.HN E 40 G.HN.49
Hydrophobic ICL3 S 223 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 S 223 - G.H5 F 354 G.H5.26
Polar H8 K 285 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 K 285 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 K 285 8x48 G.H5 G 352 G.H5.24
Ionic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 W 124 - G.HN A 42 G.HN.51
Van-der-waals ICL2 W 124 - G.HN A 42 G.HN.51
Polar TM5 H 208 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 K 123 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 123 - G.H5 N 347 G.H5.19
Hydrophobic H8 K 285 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 K 285 8x48 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 216 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 216 - G.H5 F 334 G.H5.06
Hydrophobic TM5 K 211 5x71 G.H5 F 336 G.H5.08
Hydrophobic TM5 M 212 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 212 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 W 124 - G.hns1 A 46 G.hns1.02
Van-der-waals ICL2 W 124 - G.hns1 A 46 G.hns1.02
Hydrophobic ICL2 L 120 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 K 110 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 351 G.H5.23
Polar ICL2 S 115 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 S 115 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 I 111 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 111 3x54 G.H5 C 351 G.H5.23
Polar TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 347 G.H5.19