ETB receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XVE

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41421-024-00705-9

PUBLICATION DATE

Aug. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

80 interactions (Click to see)

LIGANDS

BQ3020 - Agonist

PHYSIOLOGICAL LIGANDS

endothelin-2, endothelin-3, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 E 299 5x64 G.H5 K 370 G.H5.12
Polar TM5 E 299 5x64 G.H5 K 370 G.H5.12
Hydrophobic TM6 V 321 6x33 G.H5 V 384 G.H5.26
Van-der-waals TM6 V 321 6x33 G.H5 V 384 G.H5.26
Polar TM3 S 205 3x56 G.H5 N 377 G.H5.19
Polar TM2 N 137 2x40 G.H5 N 382 G.H5.24
Polar H8 S 390 8x47 G.H5 N 382 G.H5.24
Hydrophobic H8 S 390 8x47 G.H5 N 382 G.H5.24
Van-der-waals H8 S 390 8x47 G.H5 N 382 G.H5.24
Hydrophobic ICL2 W 206 - G.S3 V 217 G.S3.01
Polar H8 R 392 8x49 G.H5 N 382 G.H5.24
Van-der-waals H8 R 392 8x49 G.H5 N 382 G.H5.24
Hydrophobic TM3 V 203 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM5 M 296 5x61 G.H5 L 378 G.H5.20
Polar TM3 R 199 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 199 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM2 P 136 2x39 G.H5 Y 381 G.H5.23
Van-der-waals TM2 P 136 2x39 G.H5 Y 381 G.H5.23
Aromatic ICL2 W 206 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 W 206 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 W 206 - G.S1 H 41 G.S1.02
Polar TM3 A 202 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 A 202 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 A 202 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 R 199 3x50 G.H5 L 383 G.H5.25
Van-der-waals TM3 R 199 3x50 G.H5 L 383 G.H5.25
Hydrophobic ICL2 W 206 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 W 206 - G.H5 I 373 G.H5.15
Hydrophobic ICL3 L 311 - G.H4 L 336 G.H4.16
Hydrophobic TM3 A 202 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 202 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM7 L 386 7x53 G.H5 N 382 G.H5.24
Hydrophobic ICL3 K 304 - G.H5 D 371 G.H5.13
Hydrophobic TM6 V 321 6x33 G.H5 L 383 G.H5.25
Polar TM6 N 312 6x24 G.hgh4 D 313 G.hgh4.13
Hydrophobic TM7 V 389 7x56 G.H5 V 384 G.H5.26
Van-der-waals TM7 V 389 7x56 G.H5 V 384 G.H5.26
Polar TM6 H 314 6x26 G.H5 Q 375 G.H5.17
Hydrophobic TM6 H 314 6x26 G.H5 Q 375 G.H5.17
Hydrophobic ICL2 I 209 - G.H5 M 376 G.H5.18
Van-der-waals ICL2 I 209 - G.H5 M 376 G.H5.18
Ionic TM6 R 318 6x30 G.H5 D 371 G.H5.13
Polar TM6 R 318 6x30 G.H5 D 371 G.H5.13
Hydrophobic TM6 R 318 6x30 G.H5 L 374 G.H5.16
Van-der-waals TM6 R 318 6x30 G.H5 L 374 G.H5.16
Hydrophobic TM6 V 325 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM6 V 325 6x37 G.H5 L 383 G.H5.25
Polar H8 R 392 8x49 G.H5 R 379 G.H5.21
Van-der-waals H8 R 392 8x49 G.H5 R 379 G.H5.21
Hydrophobic TM6 V 321 6x33 G.H5 L 378 G.H5.20
Hydrophobic TM5 M 300 5x65 G.H5 L 378 G.H5.20
Aromatic ICL2 W 206 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 W 206 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 W 206 - G.H5 F 366 G.H5.08
Hydrophobic H8 K 391 8x48 G.H5 V 384 G.H5.26
Van-der-waals H8 K 391 8x48 G.H5 V 384 G.H5.26
Hydrophobic TM5 M 296 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 M 296 5x61 G.H5 L 383 G.H5.25
Aromatic TM6 H 314 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 H 314 6x26 G.h4s6 Y 348 G.h4s6.20
Van-der-waals TM6 H 314 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic H8 S 390 8x47 G.H5 V 384 G.H5.26
Hydrophobic TM5 M 300 5x65 G.H5 L 374 G.H5.16
Hydrophobic ICL3 L 311 - G.S6 P 351 G.S6.03
Polar ICL2 S 207 - G.S1 H 41 G.S1.02
Ionic H8 R 392 8x49 G.H5 E 380 G.H5.22
Polar H8 R 392 8x49 G.H5 E 380 G.H5.22
Hydrophobic H8 R 392 8x49 G.H5 E 380 G.H5.22
Van-der-waals H8 R 392 8x49 G.H5 E 380 G.H5.22
Hydrophobic ICL2 S 207 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 S 207 - G.H5 I 373 G.H5.15
Polar TM3 V 203 3x54 G.H5 K 370 G.H5.12
Hydrophobic ICL2 I 209 - G.H5 E 380 G.H5.22
Van-der-waals ICL2 I 209 - G.H5 E 380 G.H5.22
Polar TM6 H 314 6x26 G.S6 Y 350 G.S6.02
Aromatic TM6 H 314 6x26 G.S6 Y 350 G.S6.02
Hydrophobic TM6 H 314 6x26 G.S6 Y 350 G.S6.02
Van-der-waals TM6 H 314 6x26 G.S6 Y 350 G.S6.02
Hydrophobic ICL2 I 209 - G.H5 N 377 G.H5.19
Van-der-waals ICL2 I 209 - G.H5 N 377 G.H5.19
Polar TM3 D 198 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 D 198 3x49 G.H5 Y 381 G.H5.23
Van-der-waals TM3 D 198 3x49 G.H5 Y 381 G.H5.23
Polar ICL2 R 208 - G.H5 N 377 G.H5.19
Hydrophobic ICL2 R 208 - G.H5 N 377 G.H5.19
Aromatic ICL2 W 206 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 W 206 - G.H5 K 370 G.H5.12
Van-der-waals ICL2 W 206 - G.H5 K 370 G.H5.12