ETB receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XVH

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41421-024-00705-9

PUBLICATION DATE

Aug. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

79 interactions (Click to see)

LIGANDS

ENDOTHELIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

endothelin-2, endothelin-3, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 V 389 7x56 G.H5 L 383 G.H5.25
Ionic TM5 E 299 5x64 G.H5 K 370 G.H5.12
Polar TM3 R 201 3x52 G.H5 Y 381 G.H5.23
Hydrophobic TM6 Q 317 6x29 G.H5 V 384 G.H5.26
Van-der-waals TM6 Q 317 6x29 G.H5 V 384 G.H5.26
Hydrophobic TM6 V 321 6x33 G.H5 V 384 G.H5.26
Polar TM2 N 137 2x40 G.H5 N 382 G.H5.24
Polar H8 S 390 8x47 G.H5 N 382 G.H5.24
Hydrophobic H8 S 390 8x47 G.H5 N 382 G.H5.24
Van-der-waals H8 S 390 8x47 G.H5 N 382 G.H5.24
Hydrophobic H8 F 393 8x50 G.H5 N 382 G.H5.24
Hydrophobic ICL2 W 206 - G.S3 V 217 G.S3.01
Polar H8 R 392 8x49 G.H5 N 382 G.H5.24
Hydrophobic H8 R 392 8x49 G.H5 N 382 G.H5.24
Van-der-waals H8 R 392 8x49 G.H5 N 382 G.H5.24
Hydrophobic TM3 V 203 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 V 203 3x54 G.H5 L 378 G.H5.20
Polar TM3 R 199 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 199 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM2 P 136 2x39 G.H5 Y 381 G.H5.23
Van-der-waals TM2 P 136 2x39 G.H5 Y 381 G.H5.23
Polar TM3 A 202 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 A 202 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 A 202 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 R 199 3x50 G.H5 L 383 G.H5.25
Van-der-waals TM3 R 199 3x50 G.H5 L 383 G.H5.25
Hydrophobic ICL2 W 206 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 W 206 - G.H5 I 373 G.H5.15
Hydrophobic TM3 A 202 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 202 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM6 E 320 6x32 G.H5 V 384 G.H5.26
Hydrophobic TM6 V 321 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 V 321 6x33 G.H5 L 383 G.H5.25
Polar ICL2 K 210 - G.H5 Y 381 G.H5.23
Hydrophobic ICL2 K 210 - G.H5 Y 381 G.H5.23
Van-der-waals ICL2 K 210 - G.H5 Y 381 G.H5.23
Hydrophobic TM7 V 389 7x56 G.H5 V 384 G.H5.26
Van-der-waals TM7 V 389 7x56 G.H5 V 384 G.H5.26
Polar TM6 H 314 6x26 G.H5 Q 375 G.H5.17
Hydrophobic TM6 H 314 6x26 G.H5 Q 375 G.H5.17
Van-der-waals TM6 H 314 6x26 G.H5 Q 375 G.H5.17
Ionic TM6 R 318 6x30 G.H5 D 371 G.H5.13
Polar TM6 R 318 6x30 G.H5 D 371 G.H5.13
Van-der-waals TM6 R 318 6x30 G.H5 D 371 G.H5.13
Hydrophobic ICL2 I 209 - G.H5 M 376 G.H5.18
Hydrophobic TM6 V 325 6x37 G.H5 L 383 G.H5.25
Hydrophobic TM6 R 318 6x30 G.H5 L 374 G.H5.16
Polar H8 R 392 8x49 G.H5 R 379 G.H5.21
Van-der-waals H8 R 392 8x49 G.H5 R 379 G.H5.21
Hydrophobic TM5 M 300 5x65 G.H5 L 378 G.H5.20
Aromatic ICL2 W 206 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 W 206 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 W 206 - G.H5 F 366 G.H5.08
Polar ICL2 S 207 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 M 296 5x61 G.H5 L 383 G.H5.25
Aromatic TM6 H 314 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 H 314 6x26 G.h4s6 Y 348 G.h4s6.20
Van-der-waals TM6 H 314 6x26 G.h4s6 Y 348 G.h4s6.20
Polar ICL2 K 210 - G.H5 N 377 G.H5.19
Hydrophobic ICL2 K 210 - G.H5 E 380 G.H5.22
Van-der-waals ICL2 K 210 - G.H5 E 380 G.H5.22
Hydrophobic TM2 P 136 2x39 G.H5 E 380 G.H5.22
Van-der-waals TM2 P 136 2x39 G.H5 E 380 G.H5.22
Hydrophobic ICL2 S 207 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 S 207 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 I 212 - G.H5 E 380 G.H5.22
Polar ICL1 N 134 12x52 G.H5 E 380 G.H5.22
Polar TM3 D 198 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 D 198 3x49 G.H5 Y 381 G.H5.23
Van-der-waals TM3 D 198 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM7 V 389 7x56 G.H5 N 382 G.H5.24
Van-der-waals TM7 V 389 7x56 G.H5 N 382 G.H5.24
Polar ICL2 R 208 - G.H5 N 377 G.H5.19
Hydrophobic ICL2 I 209 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 I 209 - G.H5 I 373 G.H5.15
Aromatic ICL2 W 206 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 W 206 - G.H5 K 370 G.H5.12
Van-der-waals ICL2 W 206 - G.H5 K 370 G.H5.12