ETA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XVI

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41421-024-00705-9

PUBLICATION DATE

Aug. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

81 interactions (Click to see)

LIGANDS

ENDOTHELIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

endothelin-2, endothelin-3, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 V 193 - G.H5 N 377 G.H5.19
Hydrophobic ICL2 V 193 - G.H5 N 377 G.H5.19
Polar TM3 A 186 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 A 186 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 R 183 3x50 G.H5 L 383 G.H5.25
Van-der-waals TM3 R 183 3x50 G.H5 L 383 G.H5.25
Hydrophobic ICL2 W 190 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 W 190 - G.H5 I 373 G.H5.15
Polar ICL2 S 191 - G.H5 N 377 G.H5.19
Hydrophobic TM6 Q 300 6x29 G.H5 V 384 G.H5.26
Van-der-waals TM6 Q 300 6x29 G.H5 V 384 G.H5.26
Polar ICL4 S 373 - G.H5 N 382 G.H5.24
Hydrophobic ICL4 S 373 - G.H5 N 382 G.H5.24
Van-der-waals ICL4 S 373 - G.H5 N 382 G.H5.24
Hydrophobic TM6 V 304 6x33 G.H5 V 384 G.H5.26
Hydrophobic TM7 V 372 7x56 G.H5 L 383 G.H5.25
Aromatic TM6 H 297 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 H 297 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 H 297 6x26 G.H5 Q 375 G.H5.17
Hydrophobic TM7 V 372 7x56 G.H5 N 382 G.H5.24
Hydrophobic ICL2 W 190 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 193 - G.H5 Y 381 G.H5.23
Hydrophobic TM6 E 296 6x25 G.h4s6 Y 348 G.h4s6.20
Ionic TM6 H 297 6x26 G.H5 D 371 G.H5.13
Polar TM6 H 297 6x26 G.H5 D 371 G.H5.13
Hydrophobic TM6 H 297 6x26 G.H5 D 371 G.H5.13
Van-der-waals TM6 H 297 6x26 G.H5 D 371 G.H5.13
Hydrophobic TM6 R 301 6x30 G.H5 L 374 G.H5.16
Van-der-waals TM6 R 301 6x30 G.H5 L 374 G.H5.16
Hydrophobic TM5 M 282 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 M 282 5x65 G.H5 L 378 G.H5.20
Polar ICL2 Q 194 - G.H5 E 380 G.H5.22
Hydrophobic ICL2 Q 194 - G.H5 E 380 G.H5.22
Hydrophobic H8 F 376 8x50 G.H5 N 382 G.H5.24
Van-der-waals H8 F 376 8x50 G.H5 N 382 G.H5.24
Van-der-waals ICL4 K 375 - G.H5 R 379 G.H5.21
Polar TM3 R 185 3x52 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 185 3x52 G.H5 Y 381 G.H5.23
Hydrophobic TM2 P 115 2x39 G.H5 E 380 G.H5.22
Ionic TM5 E 281 5x64 G.H5 K 370 G.H5.12
Polar TM5 E 281 5x64 G.H5 K 370 G.H5.12
Aromatic ICL2 W 190 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 W 190 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 W 190 - G.H5 F 366 G.H5.08
Hydrophobic TM6 V 308 6x37 G.H5 L 383 G.H5.25
Aromatic ICL2 W 190 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 W 190 - G.H5 K 370 G.H5.12
Van-der-waals ICL2 W 190 - G.H5 K 370 G.H5.12
Hydrophobic TM3 V 187 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM2 P 115 2x39 G.H5 Y 381 G.H5.23
Hydrophobic TM6 H 297 6x26 G.S6 Y 350 G.S6.02
Hydrophobic TM3 R 183 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM7 V 372 7x56 G.H5 V 384 G.H5.26
Van-der-waals TM7 V 372 7x56 G.H5 V 384 G.H5.26
Hydrophobic TM3 V 187 3x54 G.H5 L 374 G.H5.16
Hydrophobic TM5 M 278 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 M 278 5x61 G.H5 L 383 G.H5.25
Hydrophobic TM6 V 304 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 V 304 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM3 D 182 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 A 186 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 W 190 - G.H5 C 369 G.H5.11
Hydrophobic ICL2 R 192 - G.H5 M 376 G.H5.18
Van-der-waals ICL2 R 192 - G.H5 M 376 G.H5.18
Hydrophobic ICL2 S 191 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 S 191 - G.H5 I 373 G.H5.15
Hydrophobic ICL2 V 193 - G.H5 E 380 G.H5.22
Van-der-waals ICL2 V 193 - G.H5 E 380 G.H5.22