apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XZJ

RESOLUTION

3.0 Å

REFERENCE

10.1016/J.CELL.2024.02.004

PUBLICATION DATE

March 20, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

66 interactions (Click to see)

LIGANDS

WN353 - Agonist

PHYSIOLOGICAL LIGANDS

apelin-36, apelin-17, apelin-13, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, [Pyr1]apelin-13, apelin receptor early endogenous ligand



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 134 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 134 - G.H5 I 344 G.H5.16
Van-der-waals TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 E 238 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 I 131 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 131 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Polar ICL1 R 62 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 62 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 62 - G.H5 D 350 G.H5.22
Ionic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 134 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 139 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 135 - G.H5 I 343 G.H5.15
Hydrophobic TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 135 - G.S3 L 194 G.S3.01
Hydrophobic TM7 F 312 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 F 312 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 353 G.H5.25
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Aromatic ICL3 F 232 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 F 232 - G.H5 K 345 G.H5.17
Hydrophobic TM5 T 227 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Ionic TM6 R 236 6x23 G.H4 E 308 G.H4.16
Polar TM6 R 236 6x23 G.H4 E 308 G.H4.16
Hydrophobic TM6 R 236 6x23 G.H4 E 308 G.H4.16
Van-der-waals TM6 R 236 6x23 G.H4 E 308 G.H4.16
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Polar TM6 R 245 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 131 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 348 G.H5.20
Ionic TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Polar H8 D 313 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 D 313 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 250 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 138 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 232 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 232 - G.H5 L 348 G.H5.20
Hydrophobic TM6 L 246 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 246 6x33 G.H5 F 354 G.H5.26
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Polar TM5 H 231 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 H 231 5x68 G.H5 K 345 G.H5.17
Ionic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 253 6x40 G.H5 L 353 G.H5.25