δ receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8Y45

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

Nov. 27, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

ADL5859 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

dynorphin A, [Met]enkephalin, β-endorphin, α-neoendorphin, dynorphin B, dynorphin A-(1-8), [Leu]enkephalin, endomorphin-1, dynorphin A-(1-13)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 258 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 R 258 6x32 G.H5 L 354 G.H5.25
Polar TM6 E 251 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 E 251 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM5 V 243 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM6 M 262 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 262 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL3 L 246 - G.H5 L 349 G.H5.20
Hydrophobic TM3 R 146 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 146 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 149 3x53 G.H5 N 348 G.H5.19
Aromatic TM6 R 258 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 258 6x32 G.H5 F 355 G.H5.26
Hydrophobic H8 E 323 8x48 G.H5 G 353 G.H5.24
Polar ICL3 R 244 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 R 244 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 244 - G.S6 Y 321 G.S6.02
Hydrophobic TM3 V 150 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 I 259 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL3 L 245 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 L 245 - G.H5 K 346 G.H5.17
Hydrophobic TM6 V 263 6x37 G.H5 L 354 G.H5.25
Hydrophobic H8 E 323 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 V 154 - G.S3 L 195 G.S3.01
Hydrophobic ICL3 L 245 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 245 - G.H5 D 342 G.H5.13
Hydrophobic TM6 K 252 6x26 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 K 252 6x26 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM5 M 236 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 M 236 5x61 G.H5 L 354 G.H5.25
Ionic ICL2 R 160 - G.H5 D 351 G.H5.22
Polar ICL2 R 160 - G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 160 - G.H5 D 351 G.H5.22
Polar ICL2 R 160 - G.H5 C 352 G.H5.23
Hydrophobic TM6 I 259 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM5 V 243 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL2 V 154 - G.H5 F 337 G.H5.08
Hydrophobic ICL2 V 154 - G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 V 154 - G.s2s3 D 194 G.s2s3.02
Van-der-waals H8 E 323 8x48 G.H5 K 350 G.H5.21
Van-der-waals ICL2 P 153 - G.H5 T 341 G.H5.12
Hydrophobic TM4 T 161 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 V 150 3x54 G.H5 I 345 G.H5.16
Polar TM2 T 84 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 T 84 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 T 84 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 153 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 153 - G.H5 I 345 G.H5.16
Hydrophobic ICL3 L 245 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 L 245 - G.h4s6 E 319 G.h4s6.12
Polar TM3 R 146 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 I 259 6x33 G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 157 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 246 - G.H5 F 355 G.H5.26
Van-der-waals ICL3 L 246 - G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 157 - G.H5 I 344 G.H5.15
Hydrophobic TM5 L 240 5x65 G.H5 L 349 G.H5.20
Polar ICL3 R 244 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 244 - G.H5 D 342 G.H5.13