BB3 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8Y53

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Sept. 11, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

MK-5046 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 149 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 149 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM6 Q 262 6x26 G.H5 Q 352 G.H5.17
Hydrophobic TM7 L 330 7x53 G.H5 N 359 G.H5.24
Van-der-waals TM7 L 330 7x53 G.H5 N 359 G.H5.24
Hydrophobic ICL3 E 255 - G.H4 V 313 G.H4.16
Van-der-waals ICL3 E 255 - G.H4 V 313 G.H4.16
Hydrophobic TM2 P 82 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 P 82 2x39 G.H5 E 357 G.H5.22
Ionic TM6 R 266 6x30 G.H5 D 348 G.H5.13
Polar TM6 R 266 6x30 G.H5 D 348 G.H5.13
Hydrophobic TM6 R 266 6x30 G.H5 D 348 G.H5.13
Van-der-waals TM6 R 266 6x30 G.H5 D 348 G.H5.13
Polar ICL2 S 158 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 S 158 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 R 266 6x30 G.H5 L 351 G.H5.16
Hydrophobic TM2 P 82 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 P 82 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 144 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL3 Q 256 - G.H4 K 310 G.H4.13
Hydrophobic ICL2 P 157 - G.HN K 27 G.HN.51
Polar ICL3 H 258 - G.h4s6 H 324 G.h4s6.13
Van-der-waals ICL3 H 258 - G.h4s6 H 324 G.h4s6.13
Hydrophobic TM6 I 269 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM5 I 251 5x72 G.H5 D 348 G.H5.13
Van-der-waals TM5 I 251 5x72 G.H5 D 348 G.H5.13
Hydrophobic TM3 V 149 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 V 149 3x54 G.H5 L 351 G.H5.16
Hydrophobic ICL3 H 258 - G.h4s6 I 325 G.h4s6.20
Van-der-waals ICL3 H 258 - G.h4s6 I 325 G.h4s6.20
Hydrophobic TM6 I 269 6x33 G.H5 L 355 G.H5.20
Hydrophobic ICL4 S 334 - G.H5 L 360 G.H5.25
Hydrophobic ICL2 P 157 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 A 148 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL3 H 258 - G.H3 W 244 G.H3.13
Polar ICL2 R 155 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 R 155 - G.H5 N 354 G.H5.19
Van-der-waals ICL2 R 155 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 153 - G.S3 V 194 G.S3.01
Hydrophobic TM3 R 145 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM6 S 265 6x29 G.H5 V 361 G.H5.26
Hydrophobic ICL2 P 152 - G.H5 K 347 G.H5.12
Polar TM2 N 83 2x40 G.H5 N 359 G.H5.24
Hydrophobic TM2 N 83 2x40 G.H5 N 359 G.H5.24
Van-der-waals TM2 N 83 2x40 G.H5 N 359 G.H5.24
Polar ICL3 E 255 - G.S6 C 326 G.S6.01
Hydrophobic ICL3 E 255 - G.S6 C 326 G.S6.01
Van-der-waals ICL3 E 255 - G.S6 C 326 G.S6.01
Hydrophobic ICL2 P 152 - G.H5 L 351 G.H5.16
Hydrophobic ICL3 Q 256 - G.H4 V 313 G.H4.16
Van-der-waals ICL3 Q 256 - G.H4 V 313 G.H4.16
Hydrophobic TM6 Q 262 6x26 G.h4s6 I 325 G.h4s6.20
Van-der-waals TM6 Q 262 6x26 G.h4s6 I 325 G.h4s6.20
Polar ICL2 P 152 - G.H5 N 354 G.H5.19
Hydrophobic ICL3 E 254 - G.H4 Y 306 G.H4.09
Hydrophobic TM7 L 333 7x56 G.H5 L 360 G.H5.25
Polar TM3 K 147 3x52 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 R 155 - G.H5 I 350 G.H5.15
Hydrophobic ICL1 M 78 12x50 G.H5 N 359 G.H5.24
Van-der-waals ICL1 M 78 12x50 G.H5 N 359 G.H5.24
Hydrophobic ICL4 S 334 - G.H5 N 359 G.H5.24
Van-der-waals ICL4 S 334 - G.H5 N 359 G.H5.24
Hydrophobic TM3 A 148 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 148 3x53 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 153 - G.H5 F 343 G.H5.08
Hydrophobic ICL3 P 252 - G.S6 Y 327 G.S6.02
Hydrophobic ICL3 E 255 - G.h4s6 I 325 G.h4s6.20
Van-der-waals ICL3 E 255 - G.h4s6 I 325 G.h4s6.20
Polar ICL4 S 334 - G.H5 V 361 G.H5.26
Hydrophobic ICL4 S 334 - G.H5 V 361 G.H5.26
Van-der-waals ICL4 S 334 - G.H5 V 361 G.H5.26
Hydrophobic ICL2 P 152 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 152 - G.H5 I 350 G.H5.15
Ionic ICL2 R 155 - G.H5 E 357 G.H5.22
Polar ICL2 R 155 - G.H5 E 357 G.H5.22
Hydrophobic ICL2 R 155 - G.H5 E 357 G.H5.22
Van-der-waals ICL2 R 155 - G.H5 E 357 G.H5.22
Hydrophobic TM5 I 251 5x72 G.S6 Y 327 G.S6.02
Hydrophobic TM5 L 244 5x65 G.H5 L 355 G.H5.20