H2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YUT

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

June 5, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

amthamine - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 123 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 123 - G.H5 I 383 G.H5.15
Hydrophobic TM5 A 209 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 209 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 209 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 125 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 125 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 124 - G.S3 V 217 G.S3.01
Hydrophobic TM3 V 120 3x54 G.H5 L 388 G.H5.20
Aromatic TM3 R 116 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 116 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 123 - G.H5 H 387 G.H5.19
Hydrophobic TM5 I 219 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM5 I 216 5x72 G.H5 R 385 G.H5.17
Polar ICL2 L 124 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 124 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 124 - G.S1 H 41 G.S1.02
Hydrophobic ICL3 W 222 - G.H4 D 343 G.H4.13
Polar ICL2 P 127 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 127 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 127 - G.hns1 R 38 G.hns1.02
Polar ICL2 R 125 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 125 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 125 - G.s2s3 D 215 G.s2s3.01
Hydrophobic TM5 Q 212 5x68 G.H5 L 394 G.H5.26
Polar TM5 Q 212 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 V 208 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 208 5x64 G.H5 Q 384 G.H5.16
Ionic H8 R 296 8x51 G.H5 E 392 G.H5.24
Polar H8 R 296 8x51 G.H5 E 392 G.H5.24
Hydrophobic H8 R 296 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 R 296 8x51 G.H5 E 392 G.H5.24
Polar TM5 Q 212 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 212 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 212 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 124 - G.S3 F 219 G.S3.03
Polar TM6 T 235 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 235 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 212 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL3 W 222 - G.h4s6 T 350 G.h4s6.03
Polar H8 D 294 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 D 294 8x49 G.H5 Q 390 G.H5.22
Polar ICL3 K 223 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 K 223 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 124 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 124 - G.H5 F 376 G.H5.08
Polar TM5 Q 212 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 212 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM6 A 232 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 205 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 205 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 208 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 123 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 I 227 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 I 227 - G.H5 L 394 G.H5.26
Ionic H8 R 293 8x48 G.H5 E 392 G.H5.24
Polar H8 R 293 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 293 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 293 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 124 - G.H5 C 379 G.H5.11
Polar H8 R 293 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 293 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 293 8x48 G.H5 R 389 G.H5.21
Hydrophobic ICL3 W 222 - G.H4 L 346 G.H4.16
Polar ICL2 P 127 - G.HN Q 35 G.HN.52
Hydrophobic TM6 T 235 6x36 G.H5 L 393 G.H5.25
Polar TM3 V 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 120 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 124 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 124 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 216 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 216 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM7 L 291 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 291 7x56 G.H5 E 392 G.H5.24
Aromatic ICL3 W 222 - G.H4 R 347 G.H4.17
Hydrophobic ICL3 W 222 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 W 222 - G.H4 R 347 G.H4.17
Ionic TM6 K 231 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 231 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 231 6x32 G.H5 E 392 G.H5.24
Polar TM3 A 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 119 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 236 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 124 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 124 - G.H5 I 383 G.H5.15
Polar ICL2 R 125 - G.s2s3 K 216 G.s2s3.02
Aromatic ICL2 Y 126 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 126 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 128 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 A 213 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 213 5x69 G.H5 L 394 G.H5.26
Ionic TM5 R 215 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 215 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 215 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 215 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM3 A 119 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 119 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 120 3x54 G.H5 Y 391 G.H5.23