SST5 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

G

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZCJ

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41401-024-01314-8

PUBLICATION DATE

July 10, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

53 interactions (Click to see)

LIGANDS

004-DTR-LYS-TYR-PHA-HYP - Agonist

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM4 R 152 4x38 G.HN E 28 G.HN.52
Polar TM4 R 152 4x38 G.HN E 28 G.HN.52
Polar TM2 T 75 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 148 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 N 310 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 310 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL2 S 146 - G.hns1 R 32 G.hns1.03
Polar TM6 K 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 245 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 148 - G.HN E 28 G.HN.52
Hydrophobic TM5 V 228 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 M 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 353 G.H5.25
Polar ICL2 L 145 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 145 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 145 - G.hns1 R 32 G.hns1.03
Polar ICL2 P 144 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 144 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 S 308 8x47 G.H5 L 353 G.H5.25
Hydrophobic ICL3 G 236 - G.S6 Y 320 G.S6.02
Hydrophobic H8 S 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 V 235 - G.H5 D 337 G.H5.09
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 Y 221 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM5 G 232 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 G 232 5x69 G.H5 D 341 G.H5.13
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM4 R 152 4x38 G.HN R 24 G.HN.48
Polar TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 141 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 141 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 224 5x61 G.H5 L 348 G.H5.20
Ionic ICL2 R 151 - G.H5 D 350 G.H5.22
Polar ICL2 R 151 - G.H5 D 350 G.H5.22
Polar ICL3 R 241 - G.h4s6 K 314 G.h4s6.08
Polar ICL3 R 241 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 R 241 - G.h4s6 D 315 G.h4s6.09
Polar TM3 D 136 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 136 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 136 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 141 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20