kisspeptin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZJE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

July 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

82 interactions (Click to see)

LIGANDS

ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 - Agonist

PHYSIOLOGICAL LIGANDS

kisspeptin-10, kisspeptin-54, kisspeptin-52, kisspeptin-14, kisspeptin-13



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 F 330 8x50 G.H5 N 359 G.H5.24
Hydrophobic H8 F 330 8x50 G.H5 N 359 G.H5.24
Hydrophobic ICL2 L 148 - G.H5 I 350 G.H5.15
Hydrophobic TM6 V 261 6x33 G.H5 V 361 G.H5.26
Hydrophobic TM6 L 264 6x36 G.H5 L 360 G.H5.25
Polar ICL2 P 147 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 151 - G.H5 I 350 G.H5.15
Hydrophobic TM6 Q 248 6x20 G.h4s6 I 325 G.h4s6.20
Hydrophobic TM3 M 136 3x46 G.H5 Y 358 G.H5.23
Van-der-waals TM3 M 136 3x46 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 147 - G.H5 K 347 G.H5.12
Hydrophobic TM5 M 227 5x61 G.H5 L 360 G.H5.25
Polar TM6 R 253 6x25 G.h4s6 D 323 G.h4s6.12
Van-der-waals TM6 R 253 6x25 G.h4s6 D 323 G.h4s6.12
Hydrophobic ICL2 P 147 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 147 - G.H5 I 350 G.H5.15
Polar TM5 P 240 5x74 G.S6 S 328 G.S6.03
Hydrophobic TM5 P 240 5x74 G.S6 S 328 G.S6.03
Van-der-waals TM5 P 240 5x74 G.S6 S 328 G.S6.03
Hydrophobic TM5 D 242 5x76 G.H4 E 309 G.H4.09
Van-der-waals TM5 D 242 5x76 G.H4 E 309 G.H4.09
Polar ICL2 H 152 - G.s2s3 S 200 G.s2s3.02
Hydrophobic ICL2 H 152 - G.s2s3 S 200 G.s2s3.02
Van-der-waals ICL2 H 152 - G.s2s3 S 200 G.s2s3.02
Polar TM6 R 253 6x25 G.h4s6 S 322 G.h4s6.11
Van-der-waals TM6 R 253 6x25 G.h4s6 S 322 G.h4s6.11
Hydrophobic ICL2 L 148 - G.S3 V 201 G.S3.01
Hydrophobic ICL2 L 148 - G.H5 K 347 G.H5.12
Polar TM3 V 143 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 354 G.H5.19
Hydrophobic H8 H 329 8x49 G.H5 K 356 G.H5.21
Hydrophobic TM3 R 140 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM5 L 245 5x79 G.H4 L 312 G.H4.12
Polar TM5 S 243 5x77 G.H4 E 309 G.H4.09
Hydrophobic TM6 L 264 6x36 G.H5 N 359 G.H5.24
Van-der-waals TM6 L 264 6x36 G.H5 N 359 G.H5.24
Hydrophobic TM6 V 257 6x29 G.H5 V 361 G.H5.26
Van-der-waals TM6 V 257 6x29 G.H5 V 361 G.H5.26
Hydrophobic TM6 V 265 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 265 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM2 I 81 2x43 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 151 - G.S3 V 201 G.S3.01
Hydrophobic TM5 L 231 5x65 G.H5 L 351 G.H5.16
Hydrophobic ICL2 L 148 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 148 - G.H5 F 343 G.H5.08
Hydrophobic TM5 A 241 5x75 G.S6 F 330 G.S6.05
Van-der-waals TM5 A 241 5x75 G.S6 F 330 G.S6.05
Van-der-waals TM2 Y 80 2x42 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 148 - G.S1 L 34 G.S1.02
Hydrophobic TM5 P 240 5x74 G.H5 F 341 G.H5.06
Van-der-waals TM5 P 240 5x74 G.H5 F 341 G.H5.06
Hydrophobic TM6 V 257 6x29 G.H5 L 355 G.H5.20
Van-der-waals TM6 V 257 6x29 G.H5 L 355 G.H5.20
Hydrophobic TM3 T 144 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 T 144 3x54 G.H5 L 355 G.H5.20
Polar TM3 R 140 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM5 D 242 5x76 G.H4 L 312 G.H4.12
Van-der-waals TM5 D 242 5x76 G.H4 L 312 G.H4.12
Hydrophobic TM6 V 261 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 261 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 151 - G.S1 L 34 G.S1.02
Hydrophobic TM5 L 231 5x65 G.H5 L 355 G.H5.20
Hydrophobic ICL2 H 152 - G.hns1 R 32 G.hns1.03
Polar TM6 K 260 6x32 G.H5 V 361 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 V 361 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 V 361 G.H5.26
Hydrophobic H8 G 327 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 G 327 8x47 G.H5 N 359 G.H5.24
Hydrophobic TM3 T 144 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM5 A 241 5x75 G.S6 H 329 G.S6.04
Polar TM7 A 324 7x54 G.H5 N 359 G.H5.24
Hydrophobic TM5 H 230 5x64 G.H5 L 351 G.H5.16
Hydrophobic TM5 D 242 5x76 G.S6 F 330 G.S6.05
Hydrophobic ICL2 R 149 - G.s2s3 S 200 G.s2s3.02
Polar TM2 T 77 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 E 357 G.H5.22
Polar TM7 Y 323 7x53 G.H5 N 359 G.H5.24
Van-der-waals TM7 Y 323 7x53 G.H5 N 359 G.H5.24
Hydrophobic TM6 V 261 6x33 G.H5 L 355 G.H5.20
Polar TM3 D 139 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 139 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 139 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM4 P 156 4x39 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 P 156 4x39 G.hns1 R 31 G.hns1.02
Polar TM5 A 241 5x75 G.S6 S 328 G.S6.03
Van-der-waals TM5 A 241 5x75 G.S6 S 328 G.S6.03
Hydrophobic H8 H 329 8x49 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM6 V 249 6x21 G.h4s6 I 325 G.h4s6.20
Hydrophobic ICL2 P 147 - G.H5 L 351 G.H5.16