GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZR5

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

June 19, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

68 interactions (Click to see)

LIGANDS

DS-8500a - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

N-palmitoylethanolamine, anandamide, N-oleoylethanolamide, SEA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 195 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 H 195 5x69 G.H5 L 394 G.H5.26
Ionic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Polar TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Polar TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 M 202 5x76 G.S6 P 361 G.S6.03
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Polar ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 M 202 5x76 G.H4 L 346 G.H4.16
Polar TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 209 5x83 G.H4 R 347 G.H4.17
Van-der-waals TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 192 5x66 G.H5 L 388 G.H5.20
Ionic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 209 5x83 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 209 5x83 G.H4 D 343 G.H4.13
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x73 G.H5 R 385 G.H5.17
Polar TM5 Q 198 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 198 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 110 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Ionic H8 K 284 8x48 G.H5 E 392 G.H5.24
Polar H8 K 284 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 284 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 195 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 111 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 111 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 P 110 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 110 - G.H5 R 380 G.H5.12
Hydrophobic ICL4 W 282 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 W 282 - G.H5 E 392 G.H5.24
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM4 S 118 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM5 G 206 5x80 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 111 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 111 - G.S3 V 217 G.S3.01
Hydrophobic TM5 G 210 5x84 G.H4 R 347 G.H4.17
Van-der-waals TM5 G 210 5x84 G.H4 R 347 G.H4.17
Hydrophobic TM5 M 202 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 K 115 - G.hns1 A 39 G.hns1.03
Polar ICL2 M 117 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 M 117 - G.hns1 R 38 G.hns1.02
Aromatic ICL2 F 111 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 111 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 111 - G.H5 R 380 G.H5.12
Hydrophobic TM5 S 196 5x70 G.H5 L 394 G.H5.26
Van-der-waals TM5 S 196 5x70 G.H5 L 394 G.H5.26
Polar TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 111 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 F 111 - G.S3 F 219 G.S3.03
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 222 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 222 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 192 5x66 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 192 5x66 G.H5 L 394 G.H5.26
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 226 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 111 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 111 - G.H5 I 383 G.H5.15
Van-der-waals TM3 A 106 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 114 - G.S1 H 41 G.S1.02
Aromatic ICL2 F 111 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 111 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 P 110 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 110 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 195 5x69 G.H5 D 381 G.H5.13
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 111 - G.S1 H 41 G.S1.02