GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZRK

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

June 19, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

60 interactions (Click to see)

LIGANDS

GSK-1292263 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

N-palmitoylethanolamine, anandamide, N-oleoylethanolamide, SEA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM5 G 206 5x80 G.h4s6 T 350 G.h4s6.03
Ionic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 192 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 199 5x73 G.H5 L 394 G.H5.26
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 106 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 106 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 T 226 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 226 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 202 5x76 G.H4 R 342 G.H4.12
Hydrophobic ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Polar TM7 W 282 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 W 282 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 W 282 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 195 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 H 195 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 191 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 191 5x65 G.H5 L 388 G.H5.20
Aromatic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals TM5 A 205 5x79 G.H4 R 342 G.H4.12
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 I 191 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Polar TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 M 202 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 M 202 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 K 222 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 222 6x32 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Ionic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Polar TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM6 K 222 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 222 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 195 5x69 G.H5 L 388 G.H5.20
Ionic TM5 H 204 5x78 G.hgh4 E 322 G.hgh4.12
Polar TM5 H 204 5x78 G.hgh4 E 322 G.hgh4.12
Hydrophobic TM5 H 204 5x78 G.hgh4 E 322 G.hgh4.12
Van-der-waals TM5 H 204 5x78 G.hgh4 E 322 G.hgh4.12
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Polar TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 209 5x83 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 209 5x83 G.H4 D 343 G.H4.13
Hydrophobic ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 G 210 5x84 G.H4 R 347 G.H4.17
Van-der-waals TM5 G 210 5x84 G.H4 R 347 G.H4.17
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Polar TM4 S 118 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Aromatic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 226 6x36 G.H5 E 392 G.H5.24
Polar TM5 Q 198 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 M 202 5x76 G.H4 L 346 G.H4.16