TA1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZSP

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.CELREP.2024.114505

PUBLICATION DATE

July 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

43 interactions (Click to see)

LIGANDS

Lysergide - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

octopamine, β-phenylethylamine, CHEMBL1160703, tyramine, (+)-Octopamine, 3-iodothyronamine, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 128 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 P 128 - G.H5 R 232 G.H5.12
Hydrophobic H8 Y 308 8x47 G.H5 E 244 G.H5.24
Hydrophobic ICL2 L 129 - G.H2 I 235 G.H2.08
Hydrophobic TM6 L 253 6x37 G.H5 L 245 G.H5.25
Hydrophobic TM5 Q 220 5x68 G.H5 L 246 G.H5.26
Polar TM3 V 125 3x54 G.H5 Q 236 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 Q 236 G.H5.16
Van-der-waals TM3 V 125 3x54 G.H5 Q 236 G.H5.16
Hydrophobic ICL2 L 129 - G.H5 C 231 G.H5.11
Aromatic ICL2 Y 131 - G.H5 H 239 G.H5.19
Hydrophobic ICL2 Y 131 - G.H5 H 239 G.H5.19
Polar TM6 K 248 6x32 G.H5 L 246 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 L 246 G.H5.26
Van-der-waals TM6 K 248 6x32 G.H5 L 246 G.H5.26
Hydrophobic ICL2 P 128 - G.H5 H 239 G.H5.19
Van-der-waals ICL2 P 128 - G.H5 H 239 G.H5.19
Ionic TM5 K 230 5x78 G.hgh4 D 175 G.hgh4.13
Polar TM5 K 230 5x78 G.hgh4 D 175 G.hgh4.13
Hydrophobic TM5 K 230 5x78 G.hgh4 D 175 G.hgh4.13
Van-der-waals TM5 K 230 5x78 G.hgh4 D 175 G.hgh4.13
Polar TM3 A 124 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 239 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM5 K 230 5x78 G.hgh4 P 173 G.hgh4.11
Van-der-waals TM5 K 230 5x78 G.hgh4 P 173 G.hgh4.11
Hydrophobic TM5 A 217 5x65 G.H5 L 240 G.H5.20
Hydrophobic ICL2 L 129 - G.S3 V 79 G.S3.01
Polar TM6 T 252 6x36 G.H5 E 244 G.H5.24
Hydrophobic TM6 T 252 6x36 G.H5 E 244 G.H5.24
Van-der-waals TM6 T 252 6x36 G.H5 E 244 G.H5.24
Hydrophobic TM5 I 224 5x72 G.H5 L 246 G.H5.26
Van-der-waals TM5 I 224 5x72 G.H5 L 246 G.H5.26
Polar TM5 Q 220 5x68 G.H5 Q 236 G.H5.16
Polar TM6 A 249 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM5 I 224 5x72 G.H5 R 237 G.H5.17
Aromatic TM3 R 121 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM7 F 307 7x56 G.H5 E 244 G.H5.24
Hydrophobic TM6 T 252 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM6 T 252 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM3 V 125 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 240 G.H5.20
Polar TM5 Q 220 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 Q 220 5x68 G.H5 R 237 G.H5.17
Van-der-waals TM5 Q 220 5x68 G.H5 R 237 G.H5.17
Hydrophobic ICL2 P 128 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 P 128 - G.H2 I 235 G.H2.08
Hydrophobic TM5 I 216 5x64 G.H5 Q 236 G.H5.16
Van-der-waals TM5 I 216 5x64 G.H5 Q 236 G.H5.16
Hydrophobic TM5 Q 220 5x68 G.H5 L 240 G.H5.20
Hydrophobic H8 Y 308 8x47 G.H5 Y 243 G.H5.23
Van-der-waals H8 Y 308 8x47 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 L 129 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 129 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 129 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 228 G.H5.08
Hydrophobic TM5 A 217 5x65 G.H5 L 245 G.H5.25
Hydrophobic TM5 A 221 5x69 G.H5 L 246 G.H5.26
Van-der-waals TM5 A 221 5x69 G.H5 L 246 G.H5.26
Hydrophobic TM5 I 224 5x72 G.h4s6 Y 210 G.h4s6.20
Van-der-waals TM5 I 224 5x72 G.h4s6 Y 210 G.h4s6.20
Hydrophobic ICL2 P 128 - G.H5 Q 236 G.H5.16
Van-der-waals ICL2 P 128 - G.H5 Q 236 G.H5.16
Hydrophobic H8 P 309 8x48 G.H5 E 244 G.H5.24
Van-der-waals H8 P 309 8x48 G.H5 E 244 G.H5.24
Hydrophobic ICL2 L 129 - G.H5 R 232 G.H5.12
Polar ICL2 Y 131 - G.H5 Y 243 G.H5.23
Hydrophobic TM5 I 213 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 245 G.H5.25
Hydrophobic ICL2 R 130 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 R 130 - G.S3 V 79 G.S3.01
Van-der-waals TM5 K 230 5x78 G.H4 R 194 G.H4.12
Hydrophobic TM3 A 124 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 243 G.H5.23
Polar H8 W 310 8x49 G.H5 Q 242 G.H5.22
Hydrophobic H8 W 310 8x49 G.H5 Q 242 G.H5.22
Van-der-waals H8 W 310 8x49 G.H5 Q 242 G.H5.22
Hydrophobic TM3 V 125 3x54 G.H5 Y 243 G.H5.23
Ionic TM5 K 230 5x78 G.H4 D 195 G.H4.13
Ionic TM6 K 248 6x32 G.H5 E 244 G.H5.24
Polar TM6 K 248 6x32 G.H5 E 244 G.H5.24
Hydrophobic TM6 K 248 6x32 G.H5 E 244 G.H5.24
Polar ICL2 R 130 - G.s2s3 D 77 G.s2s3.01
Van-der-waals ICL2 R 130 - G.s2s3 D 77 G.s2s3.01