NTS1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

86

PDB CODE

8ZYY

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

April 9, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

74 interactions (Click to see)

LIGANDS

NTS8–13 - Agonist pubchem ,

SBI-553 - Allosteric agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 L 97 - S16 K 249 C.S16.04
Van-der-waals ICL1 L 97 - S16 K 249 C.S16.04
Hydrophobic ICL3 G 293 - S5 F 60 N.S5.10
Polar ICL3 A 289 - S16 Y 248 C.S16.03
Polar C-term N 405 - S1 A 11 N.S1.05
Van-der-waals H8 H 373 8x52 s5s6 E 65 N.s5s6.03
Hydrophobic ICL3 V 295 - S5 Y 62 N.S5.12
Hydrophobic ICL3 P 292 - S8 L 128 N.S8.03
Van-der-waals ICL3 P 292 - S8 L 128 N.S8.03
Hydrophobic ICL1 Q 95 - S16 Y 248 C.S16.03
Van-der-waals ICL1 Q 95 - S16 Y 248 C.S16.03
Hydrophobic ICL3 R 294 - s5s6 G 63 N.s5s6.01
Hydrophobic C-term A 412 - H1 L 99 N.H1.02
Polar ICL1 Q 95 - S16 K 249 C.S16.04
Polar ICL3 V 295 - s5s6 E 65 N.s5s6.03
Van-der-waals ICL3 V 295 - s5s6 E 65 N.s5s6.03
Hydrophobic H8 A 369 8x48 s5s6 E 65 N.s5s6.03
Van-der-waals H8 A 369 8x48 s5s6 E 65 N.s5s6.03
Hydrophobic ICL3 P 292 - s17s18 G 285 C.s17s18.12
Polar C-term L 408 - S1 K 9 N.S1.03
Hydrophobic C-term L 408 - S1 K 9 N.S1.03
Van-der-waals C-term L 408 - S1 K 9 N.S1.03
Hydrophobic ICL3 I 290 - s5s6 E 65 N.s5s6.03
Hydrophobic C-term L 408 - S1 F 8 N.S1.02
Van-der-waals C-term L 408 - S1 F 8 N.S1.02
Polar ICL3 R 294 - S9 C 139 N.S9.01
Hydrophobic ICL3 R 294 - S9 C 139 N.S9.01
Van-der-waals ICL3 R 294 - S9 C 139 N.S9.01
Polar ICL3 A 297 - s5s6 D 66 N.s5s6.04
Hydrophobic ICL3 A 297 - s5s6 D 66 N.s5s6.04
Van-der-waals ICL3 A 297 - s5s6 D 66 N.s5s6.04
Polar C-term N 411 - ns1 R 6 N.ns1.15
Hydrophobic C-term N 411 - ns1 R 6 N.ns1.15
Van-der-waals C-term N 411 - ns1 R 6 N.ns1.15
Hydrophobic C-term N 405 - S1 K 10 N.S1.04
Hydrophobic ICL3 S 287 - s15s16 F 243 C.s15s16.03
Ionic ICL3 E 291 - s17s18 R 284 C.s17s18.11
Polar ICL3 E 291 - s17s18 R 284 C.s17s18.11
Hydrophobic ICL3 E 291 - s17s18 R 284 C.s17s18.11
Van-der-waals ICL3 E 291 - s17s18 R 284 C.s17s18.11
Polar ICL3 G 293 - s5s6 G 63 N.s5s6.01
Van-der-waals ICL3 G 293 - s5s6 G 63 N.s5s6.01
Hydrophobic ICL3 G 293 - s15s16 L 242 C.s15s16.02
Hydrophobic ICL3 V 295 - s5s6 R 64 N.s5s6.02
Van-der-waals ICL3 V 295 - s5s6 R 64 N.s5s6.02
Hydrophobic C-term A 412 - S1 V 7 N.S1.01
Hydrophobic ICL3 G 293 - S8 L 128 N.S8.03
Polar ICL1 L 97 - S16 Q 247 C.S16.02
Hydrophobic ICL1 L 97 - S16 Q 247 C.S16.02
Van-der-waals ICL1 L 97 - S16 Q 247 C.S16.02
Polar ICL3 G 293 - S9 C 139 N.S9.01
Hydrophobic H8 A 369 8x48 s5s6 D 66 N.s5s6.04
Hydrophobic ICL1 L 97 - S16 Y 248 C.S16.03
Hydrophobic C-term A 412 - ns1 T 5 N.ns1.14
Van-der-waals C-term A 412 - ns1 T 5 N.ns1.14
Hydrophobic ICL1 S 93 - S16 C 250 C.S16.05
Van-der-waals ICL1 S 93 - S16 C 250 C.S16.05
Hydrophobic ICL3 V 295 - s15s16 F 243 C.s15s16.03
Van-der-waals ICL3 V 295 - s15s16 F 243 C.s15s16.03
Polar ICL1 S 96 - S16 Q 247 C.S16.02
Hydrophobic ICL1 S 96 - S16 Q 247 C.S16.02
Van-der-waals ICL1 S 96 - S16 Q 247 C.S16.02
Hydrophobic ICL1 S 93 - s17s18 K 283 C.s17s18.10
Polar ICL1 S 93 - s17s18 L 286 C.s17s18.13
Polar C-term N 405 - s1s2 S 12 N.s1s2.01
Van-der-waals C-term N 405 - s1s2 S 12 N.s1s2.01
Polar C-term N 411 - H1 K 106 N.H1.09
Hydrophobic C-term N 411 - H1 K 106 N.H1.09
Van-der-waals C-term N 411 - H1 K 106 N.H1.09
Hydrophobic ICL3 G 293 - S5 Y 62 N.S5.12
Van-der-waals ICL3 G 293 - S5 Y 62 N.S5.12
Hydrophobic H8 N 370 8x49 s5s6 E 65 N.s5s6.03
Hydrophobic C-term N 411 - ns1 T 5 N.ns1.14
Van-der-waals C-term N 411 - ns1 T 5 N.ns1.14
Hydrophobic ICL3 R 294 - s17s18 R 284 C.s17s18.11
Van-der-waals ICL3 R 294 - s17s18 R 284 C.s17s18.11
Hydrophobic ICL3 Q 296 - s5s6 D 66 N.s5s6.04
Van-der-waals ICL3 Q 296 - s5s6 D 66 N.s5s6.04
Hydrophobic ICL1 Q 98 - S16 A 246 C.S16.01
Hydrophobic C-term H 406 - S1 K 10 N.S1.04
Polar ICL3 P 292 - S16 Y 248 C.S16.03
Hydrophobic ICL3 P 292 - S16 Y 248 C.S16.03
Van-der-waals ICL3 P 292 - S16 Y 248 C.S16.03
Van-der-waals ICL1 S 93 - S16 K 249 C.S16.04
Hydrophobic ICL3 V 295 - s15s16 L 242 C.s15s16.02
Hydrophobic C-term A 412 - H1 K 106 N.H1.09
Polar ICL1 S 93 - s17s18 G 285 C.s17s18.12
Hydrophobic ICL3 P 292 - S15 I 240 C.S15.14
Polar ICL3 E 291 - S16 Y 248 C.S16.03
Hydrophobic ICL3 E 291 - S16 Y 248 C.S16.03
Van-der-waals ICL3 E 291 - S16 Y 248 C.S16.03
Hydrophobic ICL1 K 92 - s17s18 K 283 C.s17s18.10
Van-der-waals ICL1 Q 98 - S16 Q 247 C.S16.02
Hydrophobic ICL3 Q 296 - s5s6 E 65 N.s5s6.03
Polar ICL3 V 295 - s5s6 G 63 N.s5s6.01
Van-der-waals ICL3 V 295 - s5s6 G 63 N.s5s6.01
Polar ICL1 S 96 - S16 Y 248 C.S16.03
Hydrophobic ICL1 S 96 - S16 Y 248 C.S16.03
Hydrophobic C-term A 412 - H1 R 102 N.H1.05
Polar ICL1 S 93 - s17s18 R 284 C.s17s18.11
Van-der-waals ICL1 S 93 - s17s18 R 284 C.s17s18.11