CaS receptor - Gq

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9AXF

RESOLUTION

3.5 Å

REFERENCE

10.1038/S41586-024-07331-1

PUBLICATION DATE

April 17, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

31 interactions (Click to see)

LIGANDS

tecalcet - PAM pubchem gtoplig chembl_ligand ,

Cyclomethyltryptophan - Agonist pubchem

PHYSIOLOGICAL LIGANDS

Ca2+, spermine, Mg2+, L-tryptophan



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 702 3x54 G.H5 L 245 G.H5.25
Hydrophobic C-term A 880 - G.H5 D 233 G.H5.13
Hydrophobic TM3 V 705 3x57 G.H5 N 239 G.H5.19
Hydrophobic TM3 V 705 3x57 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 714 - G.HN R 31 G.HN.49
Van-der-waals ICL2 F 714 - G.HN R 31 G.HN.49
Aromatic H8 R 873 8x55 G.h4s6 Y 210 G.h4s6.20
Hydrophobic H8 R 873 8x55 G.h4s6 Y 210 G.h4s6.20
Hydrophobic C-term A 880 - G.s4h3 L 236 G.s4h3.05
Hydrophobic ICL2 I 710 - G.HN R 31 G.HN.49
Van-der-waals ICL2 I 710 - G.HN R 31 G.HN.49
Polar H8 R 873 8x55 G.H5 Q 237 G.H5.17
Hydrophobic H8 R 873 8x55 G.H5 Q 237 G.H5.17
Van-der-waals H8 R 873 8x55 G.H5 Q 237 G.H5.17
Hydrophobic TM3 V 705 3x57 G.H5 L 240 G.H5.20
Hydrophobic ICL3 F 801 - G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 711 - G.h2s4 T 104 G.h2s4.05
Hydrophobic ICL2 T 712 - G.H5 M 238 G.H5.18
Van-der-waals ICL2 T 712 - G.H5 M 238 G.H5.18
Hydrophobic C-term T 876 - G.H5 Q 237 G.H5.17
Van-der-waals C-term T 876 - G.H5 Q 237 G.H5.17
Polar ICL2 S 713 - G.H5 N 239 G.H5.19
Hydrophobic ICL2 H 715 - G.H5 Y 243 G.H5.23
Hydrophobic ICL3 F 801 - G.s4h3 V 246 G.s4h3.15
Hydrophobic ICL2 P 711 - G.HN H 34 G.HN.52
Van-der-waals ICL2 P 711 - G.HN H 34 G.HN.52
Polar ICL1 A 645 12x52 G.H5 L 245 G.H5.25
Hydrophobic ICL1 A 645 12x52 G.H5 L 245 G.H5.25
Hydrophobic C-term T 876 - G.s4h3 L 236 G.s4h3.05
Van-der-waals C-term T 876 - G.s4h3 L 236 G.s4h3.05
Polar ICL2 S 713 - G.H5 Y 243 G.H5.23
Hydrophobic ICL2 S 713 - G.H5 Y 243 G.H5.23
Van-der-waals ICL2 S 713 - G.H5 Y 243 G.H5.23
Ionic TM4 K 717 4x25 G.H5 E 242 G.H5.22
Polar TM4 K 717 4x25 G.H5 E 242 G.H5.22
Hydrophobic TM4 K 717 4x25 G.H5 E 242 G.H5.22
Van-der-waals TM4 K 717 4x25 G.H5 E 242 G.H5.22
Hydrophobic ICL2 A 708 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 A 708 - G.H5 N 239 G.H5.19
Polar H8 R 873 8x55 G.S6 Y 212 G.S6.02
Van-der-waals H8 R 873 8x55 G.S6 Y 212 G.S6.02
Hydrophobic ICL1 K 644 12x51 G.H5 L 245 G.H5.25
Hydrophobic C-term H 879 - G.s4h3 L 236 G.s4h3.05
Van-der-waals ICL2 P 711 - G.HN R 31 G.HN.49
Hydrophobic ICL2 I 710 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 I 710 - G.H5 I 235 G.H5.15
Hydrophobic C-term T 876 - G.H5 L 240 G.H5.20
Van-der-waals C-term T 876 - G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 711 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 711 - G.H5 I 235 G.H5.15
Ionic H8 R 873 8x55 G.H5 D 233 G.H5.13
Polar H8 R 873 8x55 G.H5 D 233 G.H5.13
Hydrophobic H8 R 873 8x55 G.H5 D 233 G.H5.13
Van-der-waals H8 R 873 8x55 G.H5 D 233 G.H5.13
Hydrophobic TM3 V 705 3x57 G.H5 Y 243 G.H5.23
Van-der-waals TM3 V 705 3x57 G.H5 Y 243 G.H5.23
Hydrophobic TM3 F 706 3x58 G.s4h3 L 236 G.s4h3.05
Van-der-waals ICL2 H 715 - G.H5 E 242 G.H5.22
Polar TM2 R 648 2x36 G.H5 N 244 G.H5.24
Hydrophobic ICL2 P 711 - G.H5 M 238 G.H5.18
Van-der-waals ICL2 P 711 - G.H5 M 238 G.H5.18
Hydrophobic TM3 F 706 3x58 G.H5 L 240 G.H5.20
Hydrophobic ICL2 I 710 - G.HN A 32 G.HN.50
Hydrophobic ICL3 F 801 - G.H5 L 240 G.H5.20