PTH1 receptor - Gq

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9B5Y

RESOLUTION

3.5 Å

REFERENCE

10.1073/PNAS.2426178122

PUBLICATION DATE

March 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

61 interactions (Click to see)

LIGANDS

Long-acting parathyroid hormone analog - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36) (Human), PTHrP (Human), TIP39 (Human), PTH (Human), PTH (Mouse), PTH (Rat)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 416 6x48 G.H5 Y 356 G.H5.23
Van-der-waals TM6 L 416 6x48 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 310 3x58 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 L 349 G.H5.16
Ionic TM4 K 318 4x40 G.HN E 34 G.HN.52
Polar TM4 K 318 4x40 G.HN E 34 G.HN.52
Hydrophobic TM4 K 318 4x40 G.HN E 34 G.HN.52
Van-der-waals TM4 K 318 4x40 G.HN E 34 G.HN.52
Hydrophobic ICL4 N 463 - G.H5 N 357 G.H5.24
Hydrophobic TM6 V 412 6x44 G.H5 N 357 G.H5.24
Hydrophobic TM3 L 306 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 306 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 315 - G.hns1 R 38 G.hns1.03
Polar TM3 L 309 3x57 G.H5 N 352 G.H5.19
Hydrophobic TM3 L 309 3x57 G.H5 N 352 G.H5.19
Van-der-waals TM3 L 309 3x57 G.H5 N 352 G.H5.19
Van-der-waals ICL2 S 316 - G.hns1 R 38 G.hns1.03
Hydrophobic TM3 I 310 3x58 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 353 G.H5.20
Hydrophobic TM5 L 385 5x61 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 385 5x61 G.H5 L 353 G.H5.20
Hydrophobic TM3 L 309 3x57 G.H5 Y 356 G.H5.23
Polar TM7 C 462 7x60 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 413 6x45 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 413 6x45 G.H5 L 358 G.H5.25
Polar TM3 E 302 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 302 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 L 306 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 L 306 3x54 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 E 317 - G.HN E 34 G.HN.52
Van-der-waals ICL2 E 317 - G.HN E 34 G.HN.52
Hydrophobic TM6 S 409 6x41 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 358 G.H5.25
Polar TM2 R 219 2x46 G.H5 E 355 G.H5.22
Hydrophobic TM3 I 310 3x58 G.H5 N 352 G.H5.19
Ionic ICL2 E 317 - G.hns1 R 38 G.hns1.03
Polar ICL2 E 317 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 E 317 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 E 317 - G.hns1 R 38 G.hns1.03
Hydrophobic TM5 I 381 5x57 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 385 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM7 Y 459 7x57 G.H5 Y 356 G.H5.23
Van-der-waals TM7 Y 459 7x57 G.H5 Y 356 G.H5.23